358360-19-7

Basic information

• Product Name: 3-AMino-6,7-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one hydrochloride
• Synonyms: 1H,5H-Pyrazolo[1,2-a]pyrazol-1-one, 3-amino-6,7-dihydro-, hydrochloride (1:1);3-amino-6,7-dihydro-1H,5H-Pyrazolo[1,2-a]pyrazol-1-one hydrochloride;7-amino-2,3-dihydro-1H-pyrazolo[1,2-a]pyrazol-5-one,hydrochloride;3-AMino-6,7-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one hydrochloride
• CAS NO: 358360-19-7
• Molecular Formula: C₆H₉N₃O*ClH
• Molecular Weight: 175.6161
• Mol File: 358360-19-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-AMino-6,7-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMino-6,7-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one hydrochloride(358360-19-7)
• EPA Substance Registry System: 3-AMino-6,7-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one hydrochloride(358360-19-7)

Safety Data

• Hazardous Substances Data: 358360-19-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-6,7-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one hydrochloride is used as a potential pharmaceutical compound for its possible pharmacological activities. Given the wide range of applications of pyrazoles in medicine, 3-AMino-6,7-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one hydrochloride may be explored for its potential therapeutic effects, although further research and professional guidance are required to determine its safety and efficacy.
Used in Research and Development:
3-Amino-6,7-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one hydrochloride is used as a research compound for studying its chemical properties, reactivity, and potential applications in various fields. 3-AMino-6,7-dihydropyrazolo[1,2-a]pyrazol-1(5H)-one hydrochloride's complex structure and limited public information make it an interesting subject for scientific investigation, with the aim of uncovering its potential uses and understanding its pharmacological activity and toxicity.

Upstream product

• 358360-22-2 1-tert-butoxycarbonyl-2-cyanoacetylpyrazolidine 

Downstream Products

• 858671-14-4 4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid 
• 858671-12-2 5-{3-[(ethoxy)carbonyl]-2-[2-(4-fluorophenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}thiophene-2-carboxylic acid 
• 858671-13-3 5-{3-[(ethoxy)carbonyl]-2-[2-(4-fluorophenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}furan-2-carboxylic acid 
• 603999-10-6 4-{3-[(ethoxy)carbonyl]-2-[2-(4-fluorophenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid 
• 603999-34-4 C₂₇H₂₇F₃N₄O₆ 
• 603999-12-8 4-[3-(ethoxycarbonyl)-5-oxo-2-(trifluoromethyl)-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl]benzoic acid 
• 858671-17-7 4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-8,9-dihydro-5H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid 
• 603999-11-7 4-{3-[(ethoxy)carbonyl]-2-[2-(4-fluorophenyl)ethyl]-5-oxo-8,9-dihydro-5H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid 
• 858671-15-5 5-{3-[(ethoxy)carbonyl]-2-[2-(4-fluorophenyl)ethyl]-5-oxo-8,9-dihydro-5H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}thiophene-2-carboxylic acid 
• 858671-16-6 5-{3-[(ethoxy)carbonyl]-2-[2-(4-fluorophenyl)ethyl]-5-oxo-8,9-dihydro-5H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}furan-2-carboxylic acid 

Relevant articles and documents

Hantzsch synthesis of pyrazolo[1′,2′:1,2]pyrazolo[3,4-b] pyridines: Partial agonists of the calcitonin receptor

Small molecule calcitonin receptor agonists are of potential utility in the treatment and prevention of osteoporosis. Bicycloeneamine 1 was a useful intermediate in the synthesis of pyrazolopyridine calcitonin receptor partial agonists 2a-f. Dihydropyridi

A convenient synthesis of pyrazolidine and 3-amino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one

A convenient four-step synthesis of the aminobicyclopyrazolone hydrochloride 1·HCl was achieved starting from di-tert-butyl hydrazodiformate (8). The route entails cyclization of 8 with 1,3-dibromopropane under phase transfer conditions followed by deprotection of 1,2-di-tert-butoxycarbonylpyrazolidine (9) to give pyrazolidine hydrochloride (2·HCl). Cyanoacetylation of the latter and ring closure of the resulting cyanoacetyl pyrazolidine (7) gave 1·HCl. This novel synthesis circumvents distillation of pyrazolidine (2) and flash chromatography to provide the hydrochloride of 1 in 35-46% overall yields compared to 6% yield for the patent procedure.