- Preparation method of ibuprofen impurity B
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The invention provides a preparation method of an ibuprofen impurity B, and belongs to the technical field of preparation of drug impurity standard substances, and the preparation method comprises thefollowing steps: step 1, carrying out coupling reaction on a compound shown in a formula 1 and ethyl bromoacetate under the action of a catalyst and a first alkali to obtain a compound shown in a formula 2; 2, performing substitution reaction on the compound shown in the formula 2 and methyl iodide under the action of second alkali to obtain a compound shown in a formula 3; and 3, hydrolyzing thecompound shown in the formula 3 under the action of a third alkali to obtain the ibuprofen impurity B. The method has the advantages of simplicity in operation, short preparation period, few byproducts, easiness in purification and high yield, the prepared ibuprofen impurity B has high purity and no obvious impurity point, meets the requirements of impurity reference substances, can be used as anibuprofen impurity B standard substance, is applied to qualitative and quantitative research and detection of the ibuprofen impurity B, and has certain significance for quality control of ibuprofen bulk drugs and related preparations thereof.
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Paragraph 0026
(2021/03/13)
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