358681-61-5Relevant articles and documents
Replacement of carbohydrate sulfates by sugar C-sulfonic acid derivatives
Borbas, Aniko,Csavas, Magdolna,Szilagyi, Laszlo,Majer, Gabor,Liptak, Andras
, p. 133 - 146 (2007/10/03)
3′-Substituted p-methoxyphenyl β-lactosides and one of their 3′-epimer were synthesized. The common feature of these compounds is the presence of a strong negative charge at position C-3′ in the form of sulfonic acid moieties. The 3′,4′-diol derivative of
A strategy for the one-pot synthesis of sialylated oligosaccharides
Zhang, Zhiyuan,Niikura, Kenichi,Huang, Xue-Fei,Wong, Chi-Huey
, p. 1051 - 1054 (2007/10/03)
A new strategy has been developed for the synthesis of branched sialylated oligosaccharides using one-pot technology. Sialyl donors are in general too weak in reactivity to be used as the first glycosyl donors in the one-pot synthesis. When sialic acid is linked to a different sugar such as galactose, the reactivity is, however, significantly enhanced and can be tuned to enable the one-pot synthesis. A combination of NIS-TfOH-AgOTf was used for activation of the thioglycosides to improve the glycosylation yield when a hindered acceptor was used, as illustrated in the one-pot assembly of sialylated hexasaccharide.