- CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
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Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
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Paragraph 0185
(2014/06/11)
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- CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
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Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
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Paragraph 0185
(2014/06/11)
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- CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
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Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
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Page/Page column 43
(2012/07/14)
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- CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
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Provided are compounds represented by formula (I), their pharmaceutical compositions, and their uses for preparing medicaments as inhibitors of dipepetidyl peptidase-IV enzyme, wherein each substitutuent of formula (I) is defined as the description.
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Page/Page column 44
(2012/07/14)
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- CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
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Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
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Page/Page column 43
(2012/07/14)
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- CERTAIN DIPEPTIDYL PEPTIDASE INHIBITORS
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Disclosed are compounds represented by formula (I) and their pharmaceutical compositions, and uses thereof in the preparation of the drugs for treating a condition responsive to inhibition of dipeptidyl peptidase-IV enzyme, wherein each substituent of formula (I) is defined as the description.
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Page/Page column 44
(2012/07/14)
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- Improvement of a stereoselective biocatalytic synthesis by substrate and enzyme engineering: 2-hydroxy-(4×-oxocyclohexyl)acetonitrile as the model
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Even if biocatalysis is finding increasing application, it still has to gain widespread use in synthetic chemistry. Reasons for this are limitations that enzymes have with regard to substrate range, reaction scope, and insufficient selectivity with unnatural compounds. These shortcomings can be challenged by enzyme and/or substrate engineering, which are employed to alter substrate specificity and enhance the enzyme selectivity toward unnatural substrates. Herein, these two approaches are coupled to improve the hydroxynitrile lyase catalyzed synthesis of 2-hydroxy-(4′-oxocyclohexyl) acetonitrile (4). The ketone functionality is masked as an enol ether, and the oxynitrilase of Hevea brasiliensis is engineered towards this masked substrate to give the product with a high optical purity and to drastically lower the amount of enzyme needed.
- Avi, Manuela,Wiedner, Romana M.,Griengl, Herfried,Schwab, Helmut
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experimental part
p. 11415 - 11422
(2009/10/17)
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- Homologation of Acetals of α,β-Unsaturated Carbonyl Compounds with Diazo Esters. Synthesis of Acetals of β,γ-Unsaturated Carbonyl Compounds
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β,γ-Unsaturated acetals are conveniently prepared in good yields by boron trifluoride etherate catalyzed homologation of acetals of α,β-unsaturated aldehydes with ethyl diazoacetate.
- Doyle, Michael P.,Trudell, Mark L.,Terpstra, Jan W.
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p. 5146 - 5148
(2007/10/02)
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- Polycyclophenylpyrrolidines, their compositions and use
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Compounds of the formula STR1 where R4 X is a polycyclocoupled group and R1 and R2 are H or simple hydrocarbon and R3 has the same value and additionally simple acyl, can be made by a variety of syntheses. They have hypolipedemic and antiatherosclerotic properties, and are useful in that field.
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