- Method for synthesizing allyl phenoxyacetate
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The invention discloses a method for synthesizing allyl phenoxyacetate. The method comprises: putting phenol, caustic soda flakes and water into a flask in a proportion, carrying out stirring at 80-90DEG C for a reaction for 1-3h, removing a part of water under normal pressure, thoroughly removing water through toluene to obtain a toluene suspension of sodium phenolate, adding sodium chloroacetate into the toluene suspension of sodium phenolate, carrying out heating reflux for a reaction for 3-5h to obtain a toluene suspension of sodium phenoxyacetate, adding chloropropene and a phase transfer catalyst into the toluene suspension of sodium phenoxyacetate, carrying out heating reflux for a reaction for 6-10h, carrying out cooling, filtering to remove the catalyst and the product sodium chloride so that a crude product containing chloropropene and a toluene solvent is obtained, recovering excess chloropropene and toluene solvent from the crude product under normal pressure and carryingout rectification under vacuum to obtain an allyl phenoxyacetate finished product. Compared with the conventional method, the method provided by the invention has a high product yield, is not seriously corroded, produces the minimal amount of waste water and has environmentally friendly processes.
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Paragraph 0024; 0025; 0026; 0027
(2019/01/22)
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- Transformation of lignin model compounds to: N -substituted aromatics via Beckmann rearrangement
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Here we present the highly effective cleavage of C-C bonds in lignin model compounds for the production of N-substituted aromatics in up to 96% total yield, including benzonitriles and amides, via oxime formation followed by Beckmann rearrangement (BR). The amides could be further hydrolyzed to anilines (>92% yield) and carboxylic acids (>90% yield), respectively. In addition, the employment of a substrate with a γ-OH group will lead to the formation of C-2 monosubstituted oxazole. A one-pot process involving the BR reaction and hydrolysis has also been developed to directly afford an up to 96% total yield of benzonitriles, benzamides, and anilines. This strategy enabled us to successfully apply the BR reaction to the degradation of lignin model compounds to N-functionalized aromatic products under mild conditions.
- Wang, Yinling,Du, Yiman,He, Jianghua,Zhang, Yuetao
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supporting information
p. 3318 - 3326
(2018/07/29)
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- Production method of sodium phenoxyacetate
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An embodiment of the invention discloses a production method of sodium phenoxyacetate. The production method comprises steps as follows: (1), raw materials including 38 parts by weight of chloroacetic acid and 50 parts by weight of water are weighed, chloroacetic acid is dissolved in water, and a chloroacetic acid solution is cooled to 0 DEG C; (2), a saturated sodium carbonate solution is added to the chloroacetic acid solution during stirring at the temperature of 0 DEG C until the pH value of the solution is 7-8; (3), 26 parts by weight of phenol and 50 parts by weight of water are added to the mixed solution, a 35% sodium hydroxide solution is added until the pH value is 12, and the mixed solution is heated to 92 DEG C and subjected to a reaction for 0.5 h; (4), the mixed solution is subjected to suction filtration, solids obtained through filtration are washed and dried, and required sodium phenoxyacetate is obtained. The original production technology is improved, by the aid of a simple measure of cooling, hydrolysis of chloroacetic acid is effectively inhibited, the yield of sodium phenoxyacetate is increased, the quantity of impurities in sodium phenoxyacetate is greatly reduced, and the difficulty in purification and impurity removal of a sodium phenoxyacetate product is reduced.
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Paragraph 0012; 0013; 0014; 0015; 0016; 0017; 0018
(2017/03/08)
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- A continuous synthesis of phenoxy acetic acid method
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The invention provides a continuous synthetic method of phenoxy acetic acid and belongs to the technical field of preparation of a herbicide 2,4-D intermediate. The method comprises the following steps: simultaneously adding a sodium phenoxide aqueous solution and a sodium chloroacetate aqueous solution into a constant-pressure funnel provided with a heating sleeve to perform mixed reaction, and retaining the mixture in the constant-pressure funnel for 10-15min; overflowing reaction liquid into a 3-mouth flask containing dilute hydrochloric acid or dilute sulfuric acid at 15-20 DEG C; adjusting the pH value to 5-6 by using the dilute hydrochloric acid or dilute sulfuric acid; stirring for 0.8-1.2 hours at room temperature; and performing suction filtration to obtain white crystalline powder namely phenoxy acetic acid. According to the method provided by the invention, the sodium phenoxide aqueous solution and the sodium chloroacetate aqueous solution are simultaneously added into the constant-pressure funnel provided with the heating sleeve to perform reaction, so that the internal pressure can be kept unchanged, inverse suction can be prevented and the liquid in the funnel can flow downwards smoothly to improve the reaction efficiency; and moreover, during the preparation of the sodium chloroacetate solution, a Na2CO3 solution is dropwise added into chloroacetic acid slowly, and the chloroacetic acid is excessive, so that the reaction temperature can be beneficially controlled, and side reactions are reduced.
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Paragraph 0022; 0023; 0024; 0026; 0027; 0028; 0030-0032
(2017/08/25)
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- Finding new elicitors that induce resistance in rice to the white-backed planthopper Sogatella furcifera
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Herein we report a new way to identify chemical elicitors that induce resistance in rice to herbivores. Using this method, by quantifying the induction of chemicals for GUS activity in a specific screening system that we established previously, 5 candidate elicitors were selected from the 29 designed and synthesized phenoxyalkanoic acid derivatives. Bioassays confirmed that these candidate elicitors could induce plant defense and then repel feeding of white-backed planthopper Sogatella furcifera.
- He, Xingrui,Yu, Zhaonan,Jiang, Shaojie,Zhang, Peizhi,Shang, Zhicai,Lou, Yonggen,Wu, Jun
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supporting information
p. 5601 - 5603
(2015/11/17)
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- Carboxylic acid compositions
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A pharmaceutically acceptable composition comprising a biologically active acid compound or its salt and from one to five molar excess of a bicarbonate or carbonate.
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