Efficient synthesis of N-arylpiperazinones via a selective intramolecular Mitsunobu cyclodehydration
A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.
Weissman, Steven A.,Lewis, Stephanie,Askin, David,Volante,Reider, Paul J.
p. 7459 - 7462
(2007/10/03)
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