361345-40-6

Basic information

• Product Name: TERT-BUTYL 4-(3-AMINOBENZYL)PIPERAZINE-1-CARBOXYLATE
• Synonyms: 1-Piperazinecarboxylic acid, 4-[(3-aminophenyl)methyl]-, 1,1-dimethylethyl ester;4-(3-Aminobenzyl)piperazine,N1-BOCprotected97%;t-Butyl-4-(3-aminobenzyl)-1-piperazine-1-carboxylate;BUTTPARK 99\06-08;3-(1-BOC-PIPERAZIN-4-YL-METHYL)-ANILINE;4-(3-AMINOBENZYL)PIPERAZINE, N1-BOC PROTECTED;TERT-BUTYL 4-(3-AMINOBENZYL)PIPERAZINE-1-CARBOXYLATE;4-(3-Aminobenzyl)piperazine, N1-BOC protected 97%
• CAS NO: 361345-40-6
• Molecular Formula: C₁₆H₂₅N₃O₂
• Molecular Weight: 291.39
• Mol File: 361345-40-6.mol

Chemical Properties

• Melting Point: 107 °C
• Boiling Point: 416.6 °C at 760 mmHg
• Flash Point: 205.7 °C
• Appearance: /
• Density: 1.136 g/cm³
• Vapor Pressure: 3.79E-07mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 6.72±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTYL 4-(3-AMINOBENZYL)PIPERAZINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(3-AMINOBENZYL)PIPERAZINE-1-CARBOXYLATE(361345-40-6)
• EPA Substance Registry System: TERT-BUTYL 4-(3-AMINOBENZYL)PIPERAZINE-1-CARBOXYLATE(361345-40-6)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 361345-40-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
TERT-BUTYL 4-(3-AMINOBENZYL)PIPERAZINE-1-CARBOXYLATE is used as a precursor in the synthesis of pharmaceutical drugs and other organic compounds. Its unique structure allows for the creation of a variety of drug candidates with potential therapeutic properties.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, TERT-BUTYL 4-(3-AMINOBENZYL)PIPERAZINE-1-CARBOXYLATE is used as a key intermediate for the development of new chemical entities. Its ability to interact with biological receptors makes it a promising candidate for the design of drugs targeting specific diseases.
Used in Drug Discovery:
TERT-BUTYL 4-(3-AMINOBENZYL)PIPERAZINE-1-CARBOXYLATE is utilized in drug discovery processes to identify and optimize potential drug candidates. Its structural features facilitate the exploration of novel binding interactions with biological targets, contributing to the advancement of therapeutic agents.
Used in Chemical Compound Development:
As a building block for creating new chemical compounds, TERT-BUTYL 4-(3-AMINOBENZYL)PIPERAZINE-1-CARBOXYLATE is employed in various chemical synthesis pathways. Its versatility in forming different chemical entities makes it an essential component in the development of innovative materials and compounds for various applications.

InChI:InChI=1/C16H25N3O2/c1-16(2,3)21-15(20)19-9-7-18(8-10-19)12-13-5-4-6-14(17)11-13/h4-6,11H,7-10,12,17H2,1-3H3

Upstream product

• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 203047-33-0 tert-butyl 4-(3-nitrobenzyl)piperazine-1-carboxylate 

Downstream Products

• 1117685-94-5 tert-butyl 4-[(3-{[4-(2,6-dimethylpyridin-3-yl)oxypyridin-2-yl]-amino}phenyl)-methyl]piperazine-1-carboxylate 
• 936092-44-3 4-{3-[4-(4-chloro-3-methoxy-phenylamino)-5-methyl-pyrimidin-2-ylamino]-benzyl}-piperazine-1-carboxylic acid tert butyl ester 

Relevant articles and documents

1,3,4-OXADIAZOLE SULFONAMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.

AMINE COMPOUNDS

The present invention provide a compound of the formula:wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 and R5 are the same or different and each represents a hydrogen, etc.; R6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.

Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines

A subject of the invention is new heterocyclic or benzenic derivatives comprising a lateral chain derived from lipoic acid, which have an inhibitory activity on NO-synthase enzymes producing nitrogen monoxide NO and/or are agents allowing the regeneration