361436-29-5 Usage
Uses
Used in Pharmaceutical Industry:
N,N-Di-(tert-Butyloxycarbonyl) Serotonin is used as a precursor in the synthesis of various serotonin receptor agonists and antagonists. These compounds have potential applications in the treatment of a wide range of disorders, including depression, anxiety, and migraine.
Used in Research Applications:
N,N-Di-(tert-Butyloxycarbonyl) Serotonin is used as a research tool for studying the structure-activity relationships of serotonin and its analogs. This knowledge can help in the design and development of new drugs with improved efficacy and selectivity for specific serotonin receptors.
Used in the Preparation of Inhibitors:
N,N-Di-(tert-Butyloxycarbonyl) Serotonin is used in the preparation of inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). MK-2 is a key enzyme involved in the regulation of inflammatory responses, and its inhibition can potentially lead to the development of new therapeutic agents for the treatment of inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease.
Check Digit Verification of cas no
The CAS Registry Mumber 361436-29-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,1,4,3 and 6 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 361436-29:
(8*3)+(7*6)+(6*1)+(5*4)+(4*3)+(3*6)+(2*2)+(1*9)=135
135 % 10 = 5
So 361436-29-5 is a valid CAS Registry Number.
361436-29-5Relevant articles and documents
Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
Trujillo, John I.,Meyers, Marvin J.,Anderson, David R.,Hegde, Shridhar,Mahoney, Matthew W.,Vernier, William F.,Buchler, Ingrid P.,Wu, Kun K.,Yang, Syaluan,Hartmann, Susan J.,Reitz, David B.
, p. 4657 - 4663 (2008/02/13)
A structure-activity relationship study was conducted on a series of tetrahydro-β-carboline-1-carboxylic acid analogs in order to identify the key functionality responsible for activity against the mitogen-activated protein kinase-activated protein kinase 2 enzyme (MK-2). The compounds were further evaluated for their ability to inhibit TNFα production in U937 cells and in vivo. These compounds represent a novel structural class of compounds capable of inhibiting MK-2 with remarkable selectivity.
