- Preparation method of dibutyryl adenosine cyclophosphate compound and metal salt thereof
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The invention discloses a preparation method of a dibutyryl adenosine cyclophosphate compound and a metal salt thereof. The preparation method of the dibutyryl adenosine cyclophosphate compound comprises the following steps that in an aprotic solvent, in the presence of organic alkali, adenosine cyclophosphate shown in the formula I and n-butyric anhydride are subjected to an acylation reaction shown in the specification to obtain the dibutyryl adenosine cyclophosphate compound, wherein anions of the dibutyryl adenosine cyclophosphate compound are shown in the formula II, wherein cations of the dibutyryl adenosine cyclophosphate compound are H and/or cations formed by the organic alkali and H , and the volume-to-mass ratio of the aprotic solvent to adenosine cyclophosphate as shownin the formula I is (2-40): 1ml/g. Compared with the traditional process, the method for preparing the dibutyryl adenosine cyclophosphate compound has the advantages that single quaternary ammonium salt preparation is omitted, the solvent consumption is low, and the production period is shortened. The liquid phase content of the final product is higher than 99%, the preparation process is simplified, and the method is suitable for industrial production.
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Paragraph 0058-0059; 0065-0066; 0069-0070
(2021/02/06)
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