Asymmetric synthesis of 5-substituted pyrrolidinones via a chiral N-acyliminium equivalent
5-Substituted pyrrolidinones 5 were synthesized in good yields and with fair to good diastereoselectivities from the chiral non-racemic oxazolopyrrolidinone 4. Various nucleophiles including cuprates, silanes and phosphites were used. The chiral induction
Baussanne, Isabelle,Chiaroni, Angele,Royer, Jacques