NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are phannaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
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Page/Page column 94
(2008/06/13)
Ferulic acid and benzothiazole dimer derivatives with high binding affinity to β-amyloid fibrils
New ferulic acid and benzothiazole dimer derivatives were synthesized and evaluated by in vitro competition assay using [125I]TZDM for their specific binding affinities to Aβ fibrils. In particular, 4a showed the most excellent binding affinity (Ki = 0.53 nM), compared to PIB (Ki = 0.77 nM), for benzothiazole binding sites of Aβ1-42 fibrils. This result suggests a possibility of a potential AD diagnostic probe for detection of Aβ fibrils.
Byeon, Seong Rim,Jin, Yun Jung,Lim, Soo Jeong,Lee, Ji Hoon,Yoo, Kyung Ho,Shin, Kye Jung,Oh, Seung Jun,Kim, Dong Jin
p. 4022 - 4025
(2008/02/07)
Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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Page 31
(2008/06/13)
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