36261-62-8

Basic information

• Product Name: H-MET-GLN-OH
• Synonyms: L-MET-L-GLN OH;H-MET-GLN-OH;Met-Gln-OH;N2-L-Methionyl-L-glutamine;Nα-L-Methionyl-L-glutamine
• CAS NO: 36261-62-8
• Molecular Formula: C₁₀H₁₉N₃O₄S
• Molecular Weight: 277.34
• Mol File: 36261-62-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: H-MET-GLN-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-MET-GLN-OH(36261-62-8)
• EPA Substance Registry System: H-MET-GLN-OH(36261-62-8)

Safety Data

• Hazardous Substances Data: 36261-62-8(Hazardous Substances Data)

Upstream product

• 56-85-9 L-glutamine 
• 15776-11-1 α-methionine-N-carboxyanhydride 
• 721928-38-7 7-(N-formylmethionyl-L-glutamyl)amino-4-methylcoumarin 

Relevant articles and documents

Slow-binding inhibition of peptide deformylase by cyclic peptidomimetics as revealed by a new spectrophotometric assay

A new spectrophotometric/fluorimetric assay for peptide deformylase (PDF) has been developed by coupling the PDF reaction with that of dipeptidyl peptidase I (DPPI) and using N-formyl-Met-Lys-AMC as substrate. Removal of the N-terminal formyl group by PDF renders the dipeptide an efficient substrate of DPPI, which subsequently removes the dipeptidyl units to release 7-amino-4-methylcoumarin as the chromophore/fluorophore. The PDF reaction is conveniently monitored on a UV-Vis spectrophotometer or a fluorimeter in a continuous fashion. The utility of the assay was demonstrated by determining the catalytic activity of PDF and the inhibition constants of PDF inhibitors. These studies revealed the slow-binding behavior of a previously reported macrocyclic PDF inhibitor. This method offers several advantages over the existing PDF assays and should be particularly useful for screening PDF inhibitors in the continuous fashion.