36476-84-3

Basic information

• Product Name: 1-Benzhydryl-3-bromoazetidine
• Synonyms: 1-Benzhydryl-3-bromoazetidine;3-bromo-1-(diphenylmethyl)Azetidine
• CAS NO: 36476-84-3
• Molecular Formula: C₁₆H₁₆BrN
• Molecular Weight: 302.22
• Mol File: 36476-84-3.mol

Chemical Properties

• Boiling Point: 356.897 °C at 760 mmHg
• Flash Point: 169.646 °C
• Appearance: /
• Density: 1.383 g/cm³
• CAS DataBase Reference: 1-Benzhydryl-3-bromoazetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzhydryl-3-bromoazetidine(36476-84-3)
• EPA Substance Registry System: 1-Benzhydryl-3-bromoazetidine(36476-84-3)

Safety Data

• Hazardous Substances Data: 36476-84-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-Benzhydryl-3-bromoazetidine is used as a building block in organic synthesis for the preparation of various compounds due to its unique structure and reactivity.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-Benzhydryl-3-bromoazetidine is utilized as a key component in the development of potential pharmaceuticals, leveraging its distinctive chemical properties to create novel therapeutic agents.
Used in Agrochemical Development:
1-Benzhydryl-3-bromoazetidine is employed in the creation of agrochemicals, where its structural attributes and chemical behavior are harnessed to develop new products for agricultural applications.
Used in Chemical and Pharmaceutical Sciences Research:
1-Benzhydryl-3-bromoazetidine serves as a subject of research in chemical and pharmaceutical sciences, where its properties are explored to enhance understanding and potentially discover new applications in both fields.

Upstream product

• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 

Downstream Products

• 181941-94-6 diethyl 2-[1-(diphenylmethyl)azetidin-3-yl]propane-1,3-dioate 
• 183062-94-4 1-Benzhydryl-4-hydroxymethyl-pyrrolidin-2-one 
• 183062-93-3 1-Benzhydryl-4-hydroxymethyl-2-oxo-pyrrolidine-3-carboxylic acid 

Relevant articles and documents

Process for synthesizing 1-benzhydrylazetidin-3-formaldehyde

The invention discloses a process for synthesizing 1-benzhydrylazetidin-3-formaldehyde. The process includes the following specific steps: (1) under the action of an alkali, subjecting 1-benzhydrylazetidin-3-ol and phosphorous tribromide to reaction in a dried aprotic solvent to obtain 1-benzhydrylazetidin-3-bromo; (2) in a dried solvent, subjecting the 1-benzhydrylazetidin-3-bromine to reaction with magnesium chips to generate form Grignard reagent; subjecting the Grignard reagent to reaction with dried DMF (dimethyl formamide), carrying quenching reaction with ammonium chloride after reaction, and post-treating to obtain the target product 1-benzhydrylazetidin-3-formaldehyde. The process of the invention is stable to perform, high in yield, low in output of three wastes and low in production cost. The produced product has good quality.

A Straightforward Synthesis of Azetidin-3-ylacetic Acid

The preparation of azetidin-3-ylacetic acid from epichlorohydrin via diethyl 2-[1-(diphenylmethyl)azetidin-3-yl] propane-1,3-dioate is described.

Quantitative structure-activity relationships of antibacterial agents, 7-heterocyclic amine substituted 1-cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acids

Quantitative structure-activity relationships (QSAR) of various 7-(3-substituted-azetidin-1-yl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro -4-oxoquinoline-3-carboxylic acids, 14-25, were studied to clarify the structural requirements for 3-substituted azetidi