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CAS

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364762-86-7

TD-198946 is a synthetic compound characterized by its notable inhibitory activity against squalene synthase, an enzyme integral to cholesterol and sterol biosynthesis. It stands as a potential drug candidate for managing hyperlipidemia and cholesterol-related disorders, with demonstrated efficacy in reducing cholesterol levels in animal models. Additionally, TD-198946 has shown promise in anti-inflammatory and anti-cancer research, highlighting its versatility for therapeutic applications that extend beyond lipid regulation.

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  • 364762-86-7 Structure

  • Basic information

    1. Product Name: TD-198946
    2. Synonyms: TD-198946;1-(3-PYRIDINYLMETHYL)-4-PIPERIDINOL DIHYDROCHLORIDE
    3. CAS NO:364762-86-7
    4. Molecular Formula: C27H22N4O3S
    5. Molecular Weight: 482.55358
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 364762-86-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 699.5±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.43±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 15.87±0.20(Predicted)
    10. CAS DataBase Reference: TD-198946(CAS DataBase Reference)
    11. NIST Chemistry Reference: TD-198946(364762-86-7)
    12. EPA Substance Registry System: TD-198946(364762-86-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 364762-86-7(Hazardous Substances Data)

364762-86-7 Usage

Uses

Used in Pharmaceutical Industry:
TD-198946 is used as a cholesterol-lowering agent for its ability to inhibit squalene synthase, thereby reducing cholesterol levels and potentially managing hyperlipidemia and related conditions.
Used in Research and Development:
TD-198946 is used as a research compound for exploring its anti-inflammatory and anti-cancer properties, indicating its potential for developing new therapeutics in these areas.
Used in Drug Discovery:
TD-198946 serves as a lead compound in drug discovery efforts, given its diverse pharmacological activities and potential to impact a range of health conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 364762-86-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,4,7,6 and 2 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 364762-86:
(8*3)+(7*6)+(6*4)+(5*7)+(4*6)+(3*2)+(2*8)+(1*6)=177
177 % 10 = 7
So 364762-86-7 is a valid CAS Registry Number.

364762-86-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1H-thieno [3,4-g]indazole-6-carboxamide

1.2 Other means of identification

Product number -
Other names 2,3-dihydro-1-methyl-5-(methylthio)-1H-pyrrole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:364762-86-7 SDS

364762-86-7Upstream product

364762-86-7Downstream Products

364762-86-7Relevant articles and documents

Process for producing phospholipid-containing drug

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, (2008/06/13)

The present invention provides a pharmaceutical preparation which is safe, little irritate subjects and comprises a water-insoluble or hardly water-soluble drug at a high level, and a simple and convenient process for producing the preparation. A process for producing a pharmaceutical composition comprising a water-insoluble or hardly water-soluble drug coated with phospholipid, said process comprising mixing a solution containing the water-insoluble or hardly water-soluble drug and phospholipid in an organic solvent with an aqueous solvent, emulsifying the resultant mixture and removing the organic solvent from the emulsion thus obtained to form a phospholipid coating film on the surface of the water-insoluble or hardly water-soluble drug.

Fused heterocyclic derivatives, their production and use

-

, (2008/06/13)

There is disclosed novel fused thiophene derivatives as prophylactic and therapeutic drugs for bone or articular diseases, industrially advantageous processes for production thereof, and novel production intermediates. Said fused thiophene derivatives are

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