364794-81-0

Basic information

• Product Name: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine
• Synonyms: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine;4-(2-Morpholinoethyl)phenylboronic acid, pinacol ester;4-[2-phenyl-1-(tetraMethyl-1,3,2-dioxaborolan-2-yl)ethyl]Morpholine;4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)morpholin
• CAS NO: 364794-81-0
• Molecular Formula: C₁₈H₂₈BNO₃
• Molecular Weight: 317.23082
• Mol File: 364794-81-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine(364794-81-0)
• EPA Substance Registry System: 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine(364794-81-0)

Safety Data

• Hazardous Substances Data: 364794-81-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine is used as a reagent for the formation of carbon-carbon and carbon-nitrogen bonds in organic molecules, facilitating the production of complex organic compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine is utilized as a ligand in the synthesis of complex organic compounds, contributing to the development of new agrochemical products.
Used in Materials Science:
4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine is studied for its potential applications in materials science due to its ability to facilitate selective and efficient chemical transformations, which can lead to the development of new materials with desired properties.
Used in Catalysis:
In the field of catalysis, 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-phenethyl)morpholine is explored for its potential to enhance the efficiency of chemical reactions, making it a valuable reagent for the development of new catalytic processes.

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 736991-39-2 4-[2-(4-bromophenyl)ethyl]morpholine 
• 1746-28-7 1-bromo-4-(2-bromoethyl)benzene 
• 364793-89-5 2-(4-iodophenyl)-1-morpholin-4-ylethanone 
• 1798-06-7 (4-iodophenyl)acetic acid 
• 100839-46-1 4-[2-(4-iodophenyl)ethyl]morpholine 

Downstream Products

• 1617498-90-4 3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-5-[4-(2-morpholin-4-ylethyl)phenyl]pyridin-2-ylamine 
• 910461-31-3 (E)-3-{1-[4'-(2-morpholin-4-yl-ethyl)-biphenyl-3-sulfonyl]-1H-pyrrol-3-yl}-N-(tetrahydro-pyran-2-yloxy)-acrylamide 

Relevant articles and documents

Photo-induced thiolate catalytic activation of inert Caryl-hetero bonds for radical borylation

Substantial effort is currently being devoted to obtaining photoredox catalysts with high redox power. Yet, it remains challenging to apply the currently established methods to the activation of bonds with high bond dissociation energy and to substrates with high reduction potentials. Herein, we introduce a novel photocatalytic strategy for the activation of inert substituted arenes for aryl borylation by using thiolate as a catalyst. This catalytic system exhibits strong reducing ability and engages non-activated Caryl–F, Caryl–X, Caryl–O, Caryl–N, and Caryl–S bonds in productive radical borylation reactions, thus expanding the available aryl radical precursor scope. Despite its high reducing power, the method has a broad substrate scope and good functional-group tolerance. Spectroscopic investigations and control experiments suggest the formation of a charge-transfer complex as the key step to activate the substrates.

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS

The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.

Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors

A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds that have basic amines attached via the para position of the 7-phenyl ring, and a hydrogen atom at the C-6 position. The best compounds are low nanomolar inhibitors of Src kinase, and have potent activity against Src-transformed fibroblast cells.