Structure-function analysis of porcine cytochrome P450 3A29 in the hydroxylation of T-2 toxin as revealed by docking and mutagenesis studies
T-2 toxin, one of the type A trichothecenes, presents a potential hazard to human and animal health. Our previous work demonstrated that porcine cytochrome P450 3A29 (CYP3A29) played an important role in the hydroxylation of T-2 toxin. To identify amino a
Synthesis of HT-2 Toxin, Neosolaniol, T-2 Toxin, 3'-Hydroxy T-2 Toxin, and Sporotrichiol from Anguidine by Routes Involving Hydroxyl Inversion/Esterification
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Wani, Mansukh C.,Rector, Douglas H.,Cook, C. Edgar
p. 3468 - 3470
(2007/10/02)
THE FACILE CONVERSION OF T-2 TOXIN AND NEOSOLANIOL INTO ANGUIDINE
T-2 Toxin (5) and neosolaniol (6) are readily converted into anguidine (1) by a procedure where deoxygenation at the C-8 position is achieved, after conversion of the 3-TBDMS ether 7 of neosolaniol (6) to the β-bromide 11 for reduction to the anguidine precursor 12.
Anderson, Derek W.,Black, Robin M.,Leigh, David A.,Stoddart, Fraser J.,Williams, Nancy E.
p. 2661 - 2664
(2007/10/02)
Structural modifications of anguidin and antitumor activities of its analogues