Synthesis and capillary electrophoretic analysis of enantiomerically enriched reference standards of MDMA and its main metabolites
Enantiomerically-enriched (S)-3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites (S)-4-hydroxy-3-methoxymethamphetamine (HMMA) and (S)-3,4-dihydroxymethamphetamine (HHMA) were prepared or unequivocal identification of the differential enantioselective metabolism of these compounds as well as for its application in the analysis of biological samples. Capillary electrophoresis with cyclodextrin derivatives and a chemical correlation of (S)-MDMA, (S)-HMMA and (S)-HHMA has been performed to assign the absolute stereochemistry of major isomers in analytical standards enriched with such enantiomers. Copyright
Pizarro, Nieves,De la Torre, Rafael,Farre, Magi,Segura, Jordi,Llebaria, Amadeu,Joglar, Jesus
p. 1085 - 1092
(2007/10/03)
Synthesis of bronchospasmolytically effective β phenylethyl aminoalkyl xanthines
New theophylline and theobromine derivatives are synthesized from the β phenylethylaminoalkyl xanthines, whose phenyl substituent is substituted by one or two hydroxyl groups and partially also by other substituents. Different methods of synthesis are described, among them the production of the bronchospasmolytic 7 (3 [2 (3,5 dihydroxyphenyl) 2 hydroxy ethylamino] propyl) theophylline (reproterol . HCl).
Klingler
p. 4 - 14
(2007/10/05)
DERIVATIVES OF PHENYLISOPROPYLAMINE. PREPARATION AND CONFIGURATION OF
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PRATESI,LAMANNA,GRANA
p. 529 - 536
(2007/10/06)
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