- Efficient nitriding reagent and application thereof
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The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.
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Paragraph 0111-0112
(2021/03/31)
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- Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles
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The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chemical nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles.
- Jiao, Ning,Liu, Jianzhong,Qiu, Xu,Song, Song,Wei, Jialiang,Wen, Xiaojin,Zhang, Cheng,Zhang, Ziyao
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supporting information
p. 281 - 285
(2020/01/28)
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- Sulfated choline ionic liquid-catalyzed acetamide synthesis by grindstone method
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Sulfated choline ionic liquid (SCIL) has been found to be an efficient solid acid IL catalyst for the protection of amine groups with acetic anhydride under solvent-free grindstone conditions. The attractive features of this new catalytic methodology include its sustainability, facile work-up procedure, economic viability, and biodegradability. The SCIL catalyst was characterized using infrared spectroscopy, wide-angle X-ray scattering analysis, and scanning electron microscopy with energy dispersive X-ray spectroscopy. The catalyst could be reused six times without significant loss in activity. Furthermore, no chromatographic separations were needed to obtain the desired products.
- Kalla, Reddi Mohan Naidu,Lim, Jaehwa,Bae, Jaeyeong,Kim, Il
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supporting information
p. 1595 - 1599
(2017/04/03)
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- Efficient Heterogeneous Gold(I)-Catalyzed Direct C(sp2)–C(sp) Bond Functionalization of Arylalkynes through a Nitrogenation Process to Amides
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The first heterogeneous gold(I)-catalyzed direct C(sp2)–C(sp) bond functionalization of arylalkynes through a nitrogenation process to amides has been achieved by using an ordered mesoporous silica (MCM-41)-immobilized phosphine gold(I) complex [MCM-41-PPh3-AuCl] as catalyst and silver carbonate (Ag2CO3) as cocatalyst with trimethylsilyl azide (TMSN3) as a nitrogen source, yielding a variety of amides in moderate to excellent yields under mild conditions. This heterogeneous phosphine gold(I) complex shows the same turnover numbers as the homogeneous chloro(triphenylphosphine)gold(I) (Ph3PAuCl) and can easily be recovered by simple filtration of the reaction solution and recycled at least eight times without significant loss of activity, providing a novel, efficient, practical and economic method for the synthesis of amides from alkynes. (Figure presented.).
- Nie, Quan,Yi, Feiyan,Huang, Bin,Cai, Mingzhong
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p. 3968 - 3976
(2017/11/20)
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- A Systematic Study on the Synthesis of n-Butyl Substituted 8-Aminoquinolines
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(Chemical Equation Presented) A systematic study on the synthesis of 8-aminoquinoline derivatives with an n-butyl group at each alternate position of the quinoline ring was carried out. Skraup Reaction and its Doebner-von Miller variation were used to obtain most of the quinoline ring except for the 2-butyl-8-aminoquinolines and 4-butyl-8-aminoquinolines where the commercially available methylquinoline derivatives were used as precursors. The structures of the synthesized compounds were characterized by FTIR, 1H-NMR, COSY, 13C-NMR and HRMS spectra.
- Koseoglu, Ahmet,Gul, Turan,Acar, Ali Ersin
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p. 263 - 270
(2016/02/10)
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- 5-n-butyl-1H-benzotriazole synthesis process
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The present invention discloses a 5-n-butyl-1H-benzotriazole synthesis process, which comprises: adding concentrated sulfuric acid to acetic anhydride in a dropwise manner, and adding 4-n-butyl aniline in a dropwise manner to prepare 4-n-butyl acetanilide; adding a mixed acid solution comprising 65% concentrated nitric acid and acetic anhydride to the 4-n-butyl acetanilide in a dropwise manner to synthesize 4-n-butyl-2-nitro acetanilide; synthesizing 4-n-butyl-2-nitroaniline by using the 4-n-butyl-2-nitro acetanilide, 95% ethanol and 40% sodium hydroxide as raw materials; under the effect of a catalyst, using the 4-n-butyl-2-nitroaniline and dehydrated alcohol and sequentially using nitrogen and hydrogen to convert under a closed condition to prepare 4-n-butyl-o-phenylenediamine; and adding the 4-n-butyl-o-phenylenediamine, water and sodium nitrite to an autoclave to synthesize the 5-n-butyl-1H-benzotriazole. According to the present invention, the process equipment is simple, and the product yield is high.
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Paragraph 0011
(2016/12/01)
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- THERAPEUTICALLY ACTIVE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CHARACTERIZED AS HAVING AN IDH MUTATION
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Compounds and compositions comprising compounds useful in the treatment of cancer are described herein. The compounds and compositions can be used to modulate an isocitrate dehydrogenase (IDH) mutant (e.g., IDHIm or IDH2m) having alpha hydroxyl neoactivity
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Page/Page column 103-104
(2011/06/26)
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- MODULATORS OF CCR9 RECEPTOR AND METHODS OF USE THEREOF
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Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated
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Page/Page column 33
(2010/03/02)
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- Copper-catalyzed oxybromination and oxychlorination of primary aromatic amines using LiBr or LiCl and molecular oxygen
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Nuclear oxybromination of unprotected aromatic primary amines catalyzed by copper(II) acetate [Cu(OAc)2] under mild conditions has been developed, in which bromide ions are used as halogenating agents and dioxygen as a final oxidant. The catalyst shows not only high regioselectivity for para- or ortho-isomers but also a remarkable chemoselectivity for monobromination. Oxychlorination of aniline can also be performed under similar conditions, albeit with lower selectivities, with N-phenylacetamide being the main by-product. This simple catalytic method represents ecologically benign and economically attractive synthetic pathway to expensive low-volume aromatic haloamines.
- Menini, Luciano,Da Cruz Santos, Joyce C.,Gusevskaya, Elena V.
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experimental part
p. 2052 - 2058
(2009/08/07)
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- ARYLAMINE COMPOUND AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR
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An arylamine compound represented by formula (1): wherein R1 to R4 each independently represents a linear alkyl group or an arylalkenyl group, provided that when all of R1 to R4 represent linear alkyl groups, at least one of R1 to R4 represents a linear a
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- Nouveaux diamino-3,4 phenylalcanes et leur transformation en benzimidazolemethanethiols-2
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We report five o-phenylenediamines which are substituted by an aliphatic chain containing n carbon atoms (n = 4, 6, 8, 10, 12).We describe a well adapted general synthetic method using Schmidt's reaction.The diamines were then transformed into 2-benzimidazolemethanethiols and their related S-methyl derivatives which structures were checked by (1)H NMR.
- Krati, Noureddine,Roizard, Denis,Brembilla, Alain,Lochon, Pierre
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p. 443 - 448
(2007/10/02)
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