366457-52-5

Basic information

• Product Name: 2-Pyridinecarboxylic acid, 3-hydroxy-, hydrazide (9CI)
• Synonyms: 2-Pyridinecarboxylic acid, 3-hydroxy-, hydrazide (9CI)
• CAS NO: 366457-52-5
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.13868
• Product Categories: ALCOHOL;AMIDE
• Mol File: 366457-52-5.mol

Chemical Properties

• Appearance: /
• Density: 1.410±0.06 g/cm3(Predicted)
• PKA: 11.94±0.10(Predicted)
• CAS DataBase Reference: 2-Pyridinecarboxylic acid, 3-hydroxy-, hydrazide (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxylic acid, 3-hydroxy-, hydrazide (9CI)(366457-52-5)
• EPA Substance Registry System: 2-Pyridinecarboxylic acid, 3-hydroxy-, hydrazide (9CI)(366457-52-5)

Safety Data

• Hazardous Substances Data: 366457-52-5(Hazardous Substances Data)

Upstream product

• 62733-99-7 methyl 3-hydroxypicolinate 
• 874-24-8 3-hydroxypyridine-2-carboxylic acid 

Downstream Products

• 1254072-79-1 2-(7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridinol 
• 1254072-88-2 2-{7-[(2,4-dichloro-3-fluorophenyl)carbonyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-3-pyridinol 

Relevant articles and documents

Single-Molecule Magnet Behavior Enhanced by Synergic Effect of Single-Ion Anisotropy and Magnetic Interactions

As the simplest entity carrying intramolecular magnetic interactions, a dinuclear lanthanide complex serves as a model to investigate the effects of magnetic interactions on relaxation of magnetization, and importantly, it proves to be an efficient method to obtain robust single-molecule magnets via improving the communication between lanthanide centers. Here, three Dy2 complexes (1, 2, 3) with a similar structural motif, namely, [Dy2(HL)2(NO3)2(CH3CN)2]·2CH3CN (1), [Dy2(HL)2(NO3)2(DMF)2]·2H2O (2), and Dy2(HL)2(NO3)2(DMF)4 (3), were successfully assembled. One critical difference found in this series of complexes is that the Dy center in complex 3 is coordinated by one more solvent molecule. Surprisingly, complex 3 exhibits the best magnet-like behavior, as evidenced by the high effective barrier and butterfly-type hysteresis, although the crystal field effect around Dy ions is weakened heavily. Ab initio calculations revealed the crucial reason is the significant synergic effect between single-ion anisotropy and magnetic interactions, i.e., not only the axiality of the Dy ion is improved efficiently but also the exchange magnetic interactions increased to the same order of magnitude to the dipolar interaction in 3. This effect mainly benefits from the elaborate modification of the local coordinate environment around the Dy ion, which results in a special arrangement of anisotropy axes different from the other two complexes. It demonstrates that the magnetic interactions could be effectively enhanced by means of deliberate local structural modulation.

5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6 R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.