- Synthesis and monoamine transporter affinity of 3α-arylmethoxy-3β-arylnortropanes
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A series of 3-arylnortrop-2-enes and 3α-arylmethoxy-3β-arylnortropanes were synthesized and evaluated for binding affinity at monoamine transporters. The 3-(3,4-dichlorophenyl)nortrop-2-ene (6e) exhibited high affinity for the SERT (Ki = 0.3 nM
- Kaur, Harneet,Izenwasser, Sari,Verma, Abha,Wade, Dean,Housman, Amy,Stevens, Edwin D.,Mobley, David L.,Trudell, Mark L.
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supporting information; experimental part
p. 6865 - 6868
(2010/06/16)
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- Benzimidazolidinone derivatives as muscarinic agents
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Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
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Page/Page column 38
(2010/02/06)
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