- Synthesis, characterization and antimicrobial evaluation of (E)-4-(substitutedphenyl)-N′-(1-phenylethylidene)cyclohexane carbohydrazide derivatives
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Encouraged by the various biological activities associated with hydrazone derivatives, the present paper describes the synthesis, characterization and antimicrobial evaluation of (E)-4-(substituted phenyl)-N′-(1-phenylethylidene) cyclohexanecarbohydrazide
- Venkatasatyanarayana,Lakshmana Rao,Laxminarayana,Thirumala Chary
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p. 718 - 723
(2017/01/18)
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- Synthesis and biological evaluation of 4-(4-chlorophenyl)cyclohexane carbohydrazide derivatives as anti-bacterial agents
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The present paper describes the synthesis and antibacterial activity of novel hydrazone derivatives 4a-s derived from 4-(4-chlorophenyl)-cyclohexane carboxylic acid. All the ninteen newly synthesized novel hydrazone derivatives 4a-s were evaluated for their in vitro antibacterial activity against Staphylococcus aureus and S. pyogenes (Gram-positive bacteria) and Escherichia coli and Pseudomonas aeruginosa (Gram-negative bacteria). Antibacterial activity data revealed that the basic scaffold with R = nitrogen heterocyclic ring such as pyridine, quinoline, imidazole and indole showed significant antibacterial activity (excellent activity), whereas the hetrocyclic ring like benzo[b]furan, furan, thiophene moiety showed good antibacterial activity.
- Venkatasatyanarayana,Lakshmana Rao,Thirumala Chary,Ram,Balram,Laxminarayana
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p. 2267 - 2272
(2015/12/01)
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