- Cobalt-based nanoparticles prepared from MOF-carbon templates as efficient hydrogenation catalysts
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The development of efficient and selective nanostructured catalysts for industrially relevant hydrogenation reactions continues to be an actual goal of chemical research. In particular, the hydrogenation of nitriles and nitroarenes is of importance for the production of primary amines, which constitute essential feedstocks and key intermediates for advanced chemicals, life science molecules and materials. Herein, we report the preparation of graphene shell encapsulated Co3O4- and Co-nanoparticles supported on carbon by the template synthesis of cobalt-terephthalic acid MOF on carbon and subsequent pyrolysis. The resulting nanoparticles create stable and reusable catalysts for selective hydrogenation of functionalized and structurally diverse aromatic, heterocyclic and aliphatic nitriles, and as well as nitro compounds to primary amines (>65 examples). The synthetic and practical utility of this novel non-noble metal-based hydrogenation protocol is demonstrated by upscaling several reactions to multigram-scale and recycling of the catalyst.
- Murugesan, Kathiravan,Senthamarai, Thirusangumurugan,Sohail, Manzar,Alshammari, Ahmad S.,Pohl, Marga-Martina,Beller, Matthias,Jagadeesh, Rajenahally V.
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p. 8553 - 8560
(2018/11/30)
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- Selective catalytic transfer hydrogenation of nitriles to primary amines using Pd/C
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The catalytic transfer hydrogenation of (hetero)aryl nitriles using ammonium formate has been investigated in detail. In the presence of commercially available Pd/C, a straightforward and selective reduction is achieved without any additives under mild conditions.
- Vilches-Herrera, Marcelo,Werkmeister, Svenja,Junge, Kathrin,Boerner, Armin,Beller, Matthias
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p. 629 - 632
(2014/03/21)
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- PRODUCTION PROCESS OF AMINOMETHYL GROUP-CONTAINING BENZAMIDE COMPOUND
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ABSTRACT There is provided a process for producing an aminomethyl group-containing benzamide compound represented by the general formula (II):wherein -CONH2 and -X represent a substituent on the benzene ring and -CONH2 exists at the meta- or para-position
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Page/Page column 12
(2008/06/13)
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- Pyrazole derivatives
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This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).
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- 5-Substituted-3-aminoalkyl indole derivatives
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Compounds are disclosed of the general formula (I) STR1 wherein R1 represents halogen, alkyl, alkoxy or hydroxyl, or a group NRa Rb or CONa Rb, where Ra and Rb are hydrogen, alkyl or alkenyl or with the nitrogen atom form a saturated monocyclic 5 to 7-membered ring; R2 represents hydrogen or alkyl; R3 and R4 represent hydrogen, C1-3 alkyl or propenyl or R3 and R4 together form an aralkylidene group; Alk represents a C2-3 alkylene chain; n and m, are integers of 1 to 4 or n is zero, and their physiologically acceptable salts and solvates. The compounds are described as useful in treating pain originating from dilatation of the cranial vasculature in particular migraine and cluster headache and can be formulated in conventional manner as pharmaceutical compositions with carriers or excipients for administration by any convenient route.
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