- Tricyclic quinazolinediones
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A compound of the formula (1): wherein —X1—X2— is a group of the formula: —C(═O)—N(R7)— or —C(R8)═N— (in which R7 is hydrogen, substituted or unsubstituted alkyl, etc.; and R8 is halogen, etc.); R1, R2 and R3 are independently hydrogen, substituted or unsubstituted alkyl, etc.; and R4 is substituted or unsubstituted alkylene, or a prodrug thereof, or a pharmaceutically acceptable salt of the same, which exhibits an inhibitory activity of poly(ADP-ribose)polymerase (PARP) and is useful as remedies for diseases caused by the accelerated PARP activity such as brain ischemic disorders.
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