37010-53-0

Basic information

• Product Name: 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE
• Synonyms: 1-(2,3-DICHLORPHENYL)-1H-PYRROLE-2,5-DIONE;1-(2,3-DICHLOROPHENYL)-1H-PYRROLE-2,5-DIONE;1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE;AKOS MSC-0060;AKOS B001456;ASISCHEM C66340;ART-CHEM-BB B001456;1-(2,3-dichlorophenyl)-3-pyrroline-2,5-quinone
• CAS NO: 37010-53-0
• Molecular Formula: C₁₀H₅Cl₂NO₂
• Molecular Weight: 242.06
• Mol File: 37010-53-0.mol

Chemical Properties

• Boiling Point: 379.4°Cat760mmHg
• Flash Point: 183.2°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 5.89E-06mmHg at 25°C
• Refractive Index: 1.648
• PKA: -2.87±0.20(Predicted)
• CAS DataBase Reference: 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE(37010-53-0)
• EPA Substance Registry System: 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE(37010-53-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 37010-53-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE is used as an intermediate in the synthesis of various pharmaceuticals for its potential anti-fungal and anti-cancer properties. Its unique structure allows for the development of new drugs with enhanced efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(2,3-DICHLOROPHENYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE is used as a key intermediate in the production of agrochemicals, such as pesticides and herbicides. Its reactivity and biological activity contribute to the development of effective and targeted agrochemical products.

InChI:InChI=1/C10H5Cl2NO2/c11-6-2-1-3-7(10(6)12)13-8(14)4-5-9(13)15/h1-5H

Upstream product

• 608-27-5 2,3-dichloroaniline 
• 306935-73-9 C₁₀H₇Cl₂NO₃ 
• 108-31-6 maleic anhydride 

Downstream Products

• 307527-74-8 3-chloro-1-(2,3-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 

Relevant articles and documents

Potent Nematicidal Activity of Maleimide Derivatives on Meloidogyne incognita

Different maleimide derivatives were synthesized and assayed for their in vitro activity on the soil inhabiting, plant-parasitic nematode Meloidogyne incognita, also known as root-knot nematode. The compounds maleimide, N-ethylmaleimide, N-isopropylmaleimide, and N-isobutylmaleimide showed the strongest nematicidal activity on the second stage juveniles of the root-knot nematode with EC50/72h values of 2.6 ± 1.3, 5.1 ± 3.4, 16.2 ± 5.4, and 19.0 ± 9.0 mg/L, respectively. We also determined the nematicidal activity of copper sulfate, finding an EC50 value of 48.6 ± 29.8 mg/L. When maleimide at 1 mg/L was tested in combination with copper sulfate at 50 mg/L, we observed 100% mortality of the nematodes. We performed a GC-MS metabolomics analysis after treating nematodes with maleimide at 8 mg/L for 24 h. This analysis revealed altered fatty acids and diglyceride metabolites such as oleic acid, palmitic acid, and 1-monopalmitin. Our results suggest that maleimide may be used as a new interesting building block for developing new nematicides in combination with copper salts.

METHODS AND COMPOSITIONS INVOLVING RAD51 INHIBITORS

The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have p

An optimized RAD51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity

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Process for preparation of N-substituted maleimides

N-substituted maleimide represented by formula (2): STR1 is produced from N-substituted maleamic acid monoester represented by formula (1): STR2 in the presence of an acid catalyst by elmination of an alcohol from the monoester. The above N-substituted maleamic acid monoester represented by formula (1) is produced by esterification of N-substituted maleamic acid represented by formula (3): STR3 with an alcohol R2 -OH in the represence of an acid catalyst.