Folate-vinca alkaloid conjugates for cancer therapy: A structure-activity relationship
Vintafolide is a potent folate-targeted vinca alkaloid small molecule drug conjugate (SMDC) that has shown promising results in multiple clinical oncology studies. Structurally, vintafolide consists of 4 essential modules: (1) folic acid, (2) a hydrophili
Leamon, Christopher P.,Vlahov, Iontcho R.,Reddy, Joseph A.,Vetzel, Marilynn,Santhapuram, Hari Krishna R.,You, Fei,Bloomfield, Alicia,Dorton, Ryan,Nelson, Melissa,Kleindl, Paul,Vaughn, Jeremy F.,Westrick, Elaine
p. 560 - 568
(2014/04/03)
A simple method for the chemical modification of antitumour catharanthus (Vinca) alkaloids
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Thimmaiah,Lloyd,Sethi
p. 678 - 680
(2007/10/02)
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