370872-09-6

Basic information

• Product Name: 5-Benzoyloxy-1(2H)-isoquinolinone
• Synonyms: 5-Benzoyloxy-1(2H)-isoquinolinone;5-Benzoyloxy-3,4-dihydro-isoquinolinon-1(2H)- one;Benzoic Acid 1-Hydroxyisoquinolin-5-yl Ester;UPF 1035;5-benzoyloxyisoquinolin-1-one
• CAS NO: 370872-09-6
• Molecular Formula: C₁₆H₁₁NO₃
• Molecular Weight: 265.26344
• Product Categories: Aromatics;Heterocycles;Inhibitors
• Mol File: 370872-09-6.mol

Chemical Properties

• Melting Point: 234-236°C
• Boiling Point: 575.7 °C at 760 mmHg
• Flash Point: 302 °C
• Appearance: /
• Density: 1.29 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: 12.13±0.20(Predicted)
• CAS DataBase Reference: 5-Benzoyloxy-1(2H)-isoquinolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzoyloxy-1(2H)-isoquinolinone(370872-09-6)
• EPA Substance Registry System: 5-Benzoyloxy-1(2H)-isoquinolinone(370872-09-6)

Safety Data

• Hazardous Substances Data: 370872-09-6(Hazardous Substances Data)

Usage

Chemical Properties

Pale Beige Solid

Uses

A isoquinolinone derivative as PARP-1/PARP-2 inhibitors.

Upstream product

• 651030-44-3 5-benzoyloxyisoquinoline N-oxide 

Downstream Products

• 651030-45-4 5-benzoyloxy-1-methoxyisoquinoline 

Relevant articles and documents

4-(SUBSTITUTED ARYL)-5-HYDROXYISOQUINOLINONE DERIVATIVE

The invention provides 4-substituted aryl-5-hydroxyisoquinolinone derivatives and their pharmacologically acceptable addition salts with excellent inhibitory effect on poly (ADP-ribose) synthetase. 4-Substituted aryl-5-hydroxyisoquinolinone derivatives, r