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5-(3,4-DIMETHOXYPHENYL)-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 371157-17-4 Structure
  • Basic information

    1. Product Name: 5-(3,4-DIMETHOXYPHENYL)-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER
    2. Synonyms: 5-(3, 4-DIMETHOXYPHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER;5-(3,4-DIMETHOXYPHENYL)-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER
    3. CAS NO:371157-17-4
    4. Molecular Formula: C14H15NO5
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 371157-17-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-(3,4-DIMETHOXYPHENYL)-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-(3,4-DIMETHOXYPHENYL)-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER(371157-17-4)
    11. EPA Substance Registry System: 5-(3,4-DIMETHOXYPHENYL)-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER(371157-17-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 371157-17-4(Hazardous Substances Data)

371157-17-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 371157-17-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,1,1,5 and 7 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 371157-17:
(8*3)+(7*7)+(6*1)+(5*1)+(4*5)+(3*7)+(2*1)+(1*7)=134
134 % 10 = 4
So 371157-17-4 is a valid CAS Registry Number.

371157-17-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 5-(3,4-dimethoxyphenyl)-1,2-oxazole-3-carboxylate

1.2 Other means of identification

Product number -
Other names 5-(3,4-DIMETHOXYPHENYL)-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:371157-17-4 SDS

371157-17-4Downstream Products

371157-17-4Relevant articles and documents

Novel N-benzylpiperidine derivatives of 5-arylisoxazole-3-carboxamides as anti-Alzheimer's agents

Saeedi, Mina,Felegari, Peyman,Iraji, Aida,Hariri, Roshanak,Rastegari, Arezoo,Mirfazli, S. Sara,Edraki, Najmeh,Firuzi, Omidreza,Mahdavi, Mohammad,Akbarzadeh, Tahmineh

, (2020/11/30)

The complex pathophysiology of Alzheimer's disease (AD) has prompted researchers to develop multitarget-directed molecules to find an effective therapy against the disease. In this context, a novel series of N-(1-benzylpiperidin-4-yl)-5-arylisoxazole-3-ca

Design and synthesis of novel 5-arylisoxazole-1,3,4-thiadiazole hybrids as α-glucosidase inhibitors

Akbarzadeh, Tahmineh,Eslami, Azadeh,Faramarzi, Mohammad Ali,Mahdavi, Mohammad,Mirfazli, Seyedeh Sara,Saeedi, Mina,Zardkanlou, Mahsa

, p. 436 - 444 (2021/10/04)

Background: α-Glucosidase inhibitors have occupied a significant position in the treatment of type 2 diabetes. In this respect, the development of novel and efficient non-sugar-based inhibitors is in high demand. Objective: Design and synthesis of new 5-arylisoxazole-1,3,4-thiadiazole hybrids possessing α-glucosidase inhibitory activity were developed. Methods: Different derivatives were synthesized by the reaction of various 5-arylisoxazole-3-carboxylic acids and ethyl 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)acetate. Finally, they were evalu-ated for their α-glucosidase inhibitory activity. Results: It was found that ethyl 2-((5-(5-(2-chlorophenyl)isoxazole-3-carboxamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5j) was the most potent compound (IC50 = 180.1 μM) compared with acarbose as the reference drug (IC50 = 750.0 μM). Also, the kinetic study of 5j revealed a competitive inhibition and docking study results indicated desired interactions of that compound with amino acid residues located close to the active site of α-glucosidase. Conclusion: Good α-glucosidase inhibitory activity obtained by the title compounds introduced them as an efficient scaffold, which merits to be considered in anti-diabetic drug discovery developments.

Development of a continuous flow photoisomerization reaction converting isoxazoles into diverse oxazole products

Bracken, Cormac,Baumann, Marcus

, p. 2607 - 2617 (2020/03/11)

A continuous flow process is presented, which directly converts isoxazoles into their oxazole counterparts via a photochemical transposition reaction. This results in the first reported exploitation of this transformation to establish its scope and synthe

Design and Synthesis of Novel Arylisoxazole-Chromenone Carboxamides: Investigation of Biological Activities Associated with Alzheimer's Disease

Akbarzadeh, Tahmineh,Edraki, Najmeh,Firuzi, Omidreza,Hariri, Roshanak,Mahdavi, Mohammad,Mirfazli, Seyedeh Sara,Rastegari, Arezoo,Saeedi, Mina

, (2020/04/29)

A novel series of hybrid arylisoxazole-chromenone carboxamides were designed, synthesized, and evaluated for their cholinesterase (ChE) inhibitory activity based on the modified Ellman's method. Among synthesized compounds, 5-(3-nitrophenyl)-N-{4-[(2-oxo-

COMPOUNDS AND USES THEREOF

-

Paragraph 0694; 1158, (2019/11/11)

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Novel hybrid molecules of isoxazole chalcone derivatives: Synthesis and study of In Vitro cytotoxic activities

Thiriveedhi, Arunkumar,Nadh, Ratnakaram Venkata,Srinivasu, Navuluri,Kaushal, Kishore

, p. 576 - 582 (2018/06/06)

Background: Now-a-days, the model of “hybrid drugs” has acquired recognition in medicine due to their significant role in the treatment of different health problems. Methods: We have synthesized new series of isoxazole-chalcone conjugates (14a-m) by the C

1,2,3-Triazole-isoxazole based acetylcholinesterase inhibitors: Synthesis, biological evaluation and docking study

Najafi, Zahra,Mahdavi, Mohammad,Saeedi, Mina,Sabourian, Reyhaneh,Khanavi, Mahnaz,Safavi, Maliheh,Tehrani, Maliheh Barazandeh,Shafiee, Abbas,Foroumadi, Alireza,Akbarzadeh, Tahmineh

, p. 58 - 65 (2017/05/08)

In this work, a series of derivatives containing 1,2,3-triazole and isoxazole were synthesized. All of them were evaluated as novel dual AChE inhibitors. Most of synthesized compounds showed moderate to good inhibitory potency toward AChE. Among them, N-(

Novel indole-isoxazole hybrids: Synthesis and in vitro anti-cholinesterase activity

Vafadarnejad, Fahimeh,Saeedi, Mina,Mahdavi, Mohammad,Rafinejad, Ali,Karimpour-Razkenari, Elahe,Sameem, Bilqees,Khanavi, Mahnaz,Akbarzadeh, Tahmineh

, p. 712 - 717 (2017/07/15)

Background: This work reports synthesis and in vitro cholinesterase inhibitory activity of novel indole-isoxazole hybrids. Method: The synthetic procedure was started from different ethyl 5-Arylisoxazole-3-carboxylate derivatives. Hydrolysis and reaction

Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives

Najafi, Zahra,Mahdavi, Mohammad,Safavi, Maliheh,Saeedi, Mina,Alinezhad, Heshmatollah,Pordeli, Mahboobeh,Kabudanian Ardestani, Sussan,Shafiee, Abbas,Foroumadi, Alireza,Akbarzadeh, Tahmineh

, p. 1743 - 1747 (2015/11/09)

New derivatives of triazole-isoxazole were synthesized through a four-step reaction starting from various ethyl 4-aryl-2,4-dioxobutanoate derivatives. Finally, all compounds were examined by MTT assays for cytotoxic activity in two human breast cancer cell lines (MCF-7 and T-47D).

2-Amino-3-cyano-4-(5-arylisoxazol-3-yl)-4H-chromenes: Synthesis and in vitro cytotoxic activity

Akbarzadeh, Tahmineh,Rafinejad, Ali,Mollaghasem, Javad Malekian,Safavi, Maliheh,Fallah-Tafti, Asal,Pordeli, Mahboobeh,Ardestani, Sussan Kabudanian,Shafiee, Abbas,Foroumadi, Alireza

experimental part, p. 386 - 392 (2012/07/27)

A new series of 4-aryl-4H-chromenes bearing a 5-arylisoxazol-3-yl moiety at the C-4 position were prepared as potential anticancer agents. The in vitro cytotoxic activity of the synthesized compounds was investigated against a panel of tumor cell lines in

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