Preparation method of alpha-ketovaline calcium and intermediate thereof
The invention relates to a preparation method of alpha-ketovaline calcium and an intermediate thereof, the alpha-ketovaline calcium intermediate isopropylidene hydantoin is obtained from hydantoin and acetone under the catalysis of ammonia water, and the high-yield and high-purity isopropylidene hydantoin can be obtained without a post-treatment step of impurity removal. The alpha-ketovaline calcium is prepared from isopropylidene hydantoin, the alpha-ketovaline calcium with high yield and high purity can also be obtained, and the method is suitable for industrial large-scale production.
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Paragraph 0038; 0041
(2021/12/07)
PROCESS FOR MAKING N-SULFONATED-AMINO ACID DERIVATIVES
This invention relates to a process for preparing optically active α -amino acid substrates which are used to make potent lethal factor (LF) inhibitors for the treatment of anthrax. This invention further relates to a process for synthesis of potent LF-inhibitors for the treatment of anthrax. Specifically, the invention concerns a novel, high-yielding and highly enantioselective asymmetric hydrogenation reaction of a tetrasubstituted ene-sulfonamide acid or ester.
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Page/Page column 26
(2008/06/13)
Synthesis of 4,4-dimethyl-2,3-furanedione
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Fizet
p. 2024 - 2028
(2007/10/02)
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