Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives
The alkaloid isaindigotone (1a) and seven derivatives have been synthesized to study their influence on several leukocyte functions and the generation of inflammatory mediators. Isaindigotone (1a) was found to be a scavenger of superoxide generated either
A convenient divergent approach to the alkaloids isaindigotone and luotonin A
Deoxyvasicinone has been used as the key intermediate to prepare the alkaloids isaindigotone and luotonin A. This intermediate is directly converted into isaindigotone by condensation with 4-acetoxy-3,5-dimethoxybenzaldehyde; alternatively oxidation with SeO2 afforded the pyrrolo[2,1-b]quinazoline-3,9-dione, a putative precursor of the luotonin A.
Molina,Tarraga,Gonzalez-Tejero
p. 1523 - 1525
(2007/10/03)
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