371967-21-4

Basic information

• Product Name: 4,4-DIFLUORO-1-(4-FLUORO-PHENYL)-BUTANE-1,3-DIONE
• Synonyms: ART-CHEM-BB B007363;AKOS MSC-0351;AKOS B007363;4,4-DIFLUORO-1-(4-FLUORO-PHENYL)-BUTANE-1,3-DIONE
• CAS NO: 371967-21-4
• Molecular Formula: C₁₀H₇F₃O₂
• Molecular Weight: 216.16
• Mol File: 371967-21-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,4-DIFLUORO-1-(4-FLUORO-PHENYL)-BUTANE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DIFLUORO-1-(4-FLUORO-PHENYL)-BUTANE-1,3-DIONE(371967-21-4)
• EPA Substance Registry System: 4,4-DIFLUORO-1-(4-FLUORO-PHENYL)-BUTANE-1,3-DIONE(371967-21-4)

Safety Data

• Hazardous Substances Data: 371967-21-4(Hazardous Substances Data)

Upstream product

• 454-31-9 ethyl difluoroacetate 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 1418197-16-6 5-(difluoromethyl)-3-(4-fluorophenyl)isoxazole 
• 1418197-32-6 [5-difluoromethyl-3-(4-fluorophenyl)isoxazol-4-yl]-(4-trifluoromethylphenyl)methanol 
• 1418197-31-5 2,2-difluoro-2-[3-(4-fluorophenyl)isoxazol-5-yl]-1-(4-trifluoromethylphenyl)ethanol 
• 1418197-30-4 [5-difluoromethyl-3-(4-fluorophenyl)isoxazol-4-yl]-(4-methoxyphenyl)methanol 
• 1418197-29-1 2,2-difluoro-2-[3-(4-fluorophenyl)isoxazol-5-yl]-1-(4-methoxyphenyl)ethanol 
• 1418197-28-0 [5-difluoromethyl-3-(4-fluorophenyl)isoxazol-4-yl]furan-2-ylmethanol 
• 1418197-27-9 2,2-difluoro-2-[3-(4-fluorophenyl)isoxazol-5-yl]-1-furan-2-ylethanol 
• 1418197-26-8 [5-difluoromethyl-3-(4-fluorophenyl)isoxazol-4-yl]phenylmethanol 
• 1418197-25-7 2,2-difluoro-2-[3-(4-fluorophenyl)isoxazol-5-yl]-1-phenylethanol 

Relevant articles and documents

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine

Structure-activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes are described. This led to the identification of 12a as a lead candidate for further progression. The in vitro and in vivo activity of 12a for the canine COX-2 enzyme as well as its in vivo efficacy and pharmacokinetic properties in dog are highlighted.

Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents

The present invention relates to compounds of the formula wherein R2, R3, R6and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).