371975-46-1

Basic information

• Product Name: tert-butyl 4-hydroxy-4-vinylpiperidine-1-carboxylate
• Synonyms: tert-butyl 4-hydroxy-4-vinylpiperidine-1-carboxylate
• CAS NO: 371975-46-1
• Molecular Formula: C12H21NO3
• Molecular Weight: 227.30004
• Mol File: 371975-46-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 4-hydroxy-4-vinylpiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-hydroxy-4-vinylpiperidine-1-carboxylate(371975-46-1)
• EPA Substance Registry System: tert-butyl 4-hydroxy-4-vinylpiperidine-1-carboxylate(371975-46-1)

Safety Data

• Hazardous Substances Data: 371975-46-1(Hazardous Substances Data)

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 1401728-93-5 C₂₉H₃₈N₄O₃ 

Relevant articles and documents

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Synthesis of carbo- and heterocyclic aldehydes bearing an adjacent donor group - Ozonolysis versus OsO4/KIO4-oxidation

The synthesis of carbo- and heterocyclic aldehydes bearing an ipso-methoxy group is investigated. The synthetic sequence is based on an initial Grignard addition of an olefin to a cyclic ketone followed by methylation of the resulting tertiary alcohol. The terminal olefin serves as precursor for the aldehyde functionality. Oxidation by ozonolysis turned out to depend significantly on the distance of the donor methoxy group. The observed side reactions could be circumvented by applying a one-pot OsO4 mediated diol formation followed by Malaprade oxidation using KIO4. A series of carbo- and heterocyclic precursors were successfully converted to the title products. Springer-Verlag 2004.