372098-59-4

Basic information

• Product Name: 3-(4-chlorophenyl)-N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide
• Synonyms: 3-(4-chlorophenyl)-N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide
• CAS NO: 372098-59-4
• Molecular Formula: C₂₃H₁₈ClN₃O₂
• Molecular Weight: 403.86092
• Mol File: 372098-59-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-chlorophenyl)-N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide(372098-59-4)
• EPA Substance Registry System: 3-(4-chlorophenyl)-N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxamide(372098-59-4)

Safety Data

• Hazardous Substances Data: 372098-59-4(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 104-94-9 4-methoxy-aniline 
• 372107-14-7 1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid 
• 57845-08-6 p-chloroacetophenone phenylhydrazone 
• 36663-00-0 1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde 

Relevant articles and documents

Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents

A series of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives have been designed, synthesized and evaluated for their potential antiproliferation activity and Aurora-A kinase inhibitory activity. Among all the compounds, compound 10e possessed the most potent biological activity against HCT116 and MCF-7 cell lines with IC50 values of 0.39 ± 0.06 μM and 0.46 ± 0.04 μM, respectively, which were comparable to the positive control. Compound 10e also exhibited significant Aurora-A kinase inhibitory activity (IC50 = 0.16 ± 0.03 μM). Docking simulation was performed to position compound 10e into the active site of Aurora-A kinase, in order to get the probable binding model for further study. The results of Western-blot assay demonstrated that compound 10e possessed good Aurora-A kinase inhibitory activity against HCT116. Based on the preliminary results, it is deduced that compound 10e with potent Aurora-A kinase inhibitory activity may be a potential anticancer agent.