372508-77-5

Basic information

• Product Name: 2,4-DIBROMO-6-[(2-METHYL-1H-INDOL-3-YL)(MORPHOLIN-4-YL)METHYL]PHENOL
• Synonyms: 2,4-DIBROMO-6-[(2-METHYL-1H-INDOL-3-YL)(MORPHOLIN-4-YL)METHYL]PHENOL;TOSLAB 97769
• CAS NO: 372508-77-5
• Molecular Formula: C20H20Br2N2O2
• Molecular Weight: 480.19
• Mol File: 372508-77-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-DIBROMO-6-[(2-METHYL-1H-INDOL-3-YL)(MORPHOLIN-4-YL)METHYL]PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIBROMO-6-[(2-METHYL-1H-INDOL-3-YL)(MORPHOLIN-4-YL)METHYL]PHENOL(372508-77-5)
• EPA Substance Registry System: 2,4-DIBROMO-6-[(2-METHYL-1H-INDOL-3-YL)(MORPHOLIN-4-YL)METHYL]PHENOL(372508-77-5)

Safety Data

• Hazardous Substances Data: 372508-77-5(Hazardous Substances Data)

Upstream product

• 95-20-5 2-methyl-1H-indole 
• 239438-66-5 (3,5-dibromo-2-hydroxyphenyl)dimorpholinomethane 
• 90-59-5 3,5-Dibromosalicylaldehyde 

Relevant articles and documents

The hit-to-lead optimization of 1,2,3,4,4a,9a-hexahydro-1H-xanthenes as glucocorticoid receptor antagonists

The structure-activity relationship (SAR) study of a 1,2,3,4,4a,9a- hexahydro-1H-xanthene series of selective, human glucocorticoid receptor α (hGRα) antagonists is reported. Compounds were screened using hydroxyapatite-based GR binding and MMTV-Luc co-transfection reporter gene assays. Four different regions of the scaffold were modified to assess the effects on hGRα antagonism and related potency. Compound 8d exhibits an 8-fold better bioactivity than the original hit 1a, as well as an improved chemical stability, which make it a promising lead for the subsequent optimization.

Reactions of 2-methylindole with morpholinals of substituted salicylaldehydes

Fusion of 2-methylindole with morphinals of substituted salicylaldehydes (in a ratio of 1:1) afforded 3-[(2-hydroxyaryl)morpholinomethyl] -2-methylindoles as normal products of the Mannich reaction. In some cases, the reactions with an excess of 2-methyli