- GRANZYME B DIRECTED IMAGING AND THERAPY
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Provided herein are compounds of Formula (I) below that are useful for imaging Granzyme B. Methods of imaging Granzyme B and treating an immunoregulatory abnormality, pharmaceutical compositions, and kits comprising the Granzyme B imaging agents are also provided.
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Paragraph 0219; 0238; 0243
(2020/08/28)
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- Towards the development of new subtype-specific muscarinic receptor radiopharmaceuticals - Radiosynthesis and ex vivo biodistribution of [ 18F]3-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethylthio)-1,2, 5-thiadiazol-3-yl)-1-methyl-1,2,5,6-tetrahydropyrid
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Muscarinic receptors have been implicated in neurological disorders including Alzheimer's disease, Parkinson's disease, and schizophrenia. Nineteen derivatives of thiadiazolyltetrahydropyridine (TZTP), a core that has previously shown high affinities towa
- Van Oosten, Erik M.,Wilson, Alan A.,Mamo, David C.,Pollock, Bruce G.,Mulsant, Benoit H.,Houle, Sylvain,Vasdev, Neil
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experimental part
p. 1222 - 1232
(2011/02/24)
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- BENZYLBENZENE DERIVATIVES AND METHODS OF USE
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Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
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Page/Page column 76
(2009/04/25)
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