- Multi-enzymatic cascade reactions with Escherichia coli-based modules for synthesizing various bioplastic monomers from fatty acid methyl esters?
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Multi-enzymatic cascade reaction systems were designed to generate biopolymer monomers using Escherichia coli-based cell modules, capable of carrying out one-pot reactions. Three cell-based modules, including a ω-hydroxylation module (Cell-Hm) to convert fatty acid methyl esters (FAMEs) to ω-hydroxy fatty acids (ω-HFAs), an amination module (Cell-Am) to convert terminal alcohol groups of the substrate to amine groups, and a reduction module (Cell-Rm) to convert the carboxyl groups of fatty acids to alcohol groups, were constructed. The product-oriented assembly of these cell modules involving multi-enzymatic cascade reactions generated ω-ADAs (up to 46 mM), α,ω-diols (up to 29 mM), ω-amino alcohols (up to 29 mM) and α,ω-diamines (up to 21 mM) from 100 mM corresponding FAME substrates with varying carbon chain length (C8, C10, and C12). Finally 12-ADA and 1,12-diol were purified with isolated yields of 66.5% and 52.5%, respectively. The multi-enzymatic cascade reactions reported herein present an elegant ‘greener’ alternative for the biosynthesis of various biopolymer monomers from renewable saturated fatty acids.
- Jung, Hyunsang,Kim, Byung-Gee,Kim, Ye Chan,Park, Beom Gi,Patil, Mahesh D.,Sarak, Sharad,Yoo, Hee-Wang,Yun, Hyungdon
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supporting information
p. 2222 - 2231
(2022/04/03)
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- METHOD FOR PREPARING DICYANOALKANE AND BIS(AMINOMETHYL)ALKANE
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A method for preparing a dicyanoalkane may omit a filtration for a catalyst after a cyanation reaction can by carrying out the cyanation reaction in a state in which precipitation of a metal catalyst is suppressed. A method for preparing a dicyanoalkane may involve cyanating one or more aliphatic dicarboxylic acids and/or salt(s) thereof with an ammonia source in the presence of a predetermined compound and a catalyst, wherein, in the cyanation, the amount of the predetermined compound is maintained at a predetermined amount or more with respect to the catalyst.
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Paragraph 0097; 0098
(2021/05/14)
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- Imprinted Apportionment of Functional Groups in Multivariate Metal-Organic Frameworks
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Sophisticated chemical processes widely observed in biological cells require precise apportionment regulation of building units, which inspires researchers to develop tailorable architectures with controllable heterogeneity for replication, recognition and information storage. However, it remains a substantial challenge to endow multivariate materials with internal sequences and controllable apportionments. Herein, we introduce a novel strategy to manipulate the apportionment of functional groups in multivariate metal-organic frameworks (MTV-MOFs) by preincorporating interlocked linkers into framework materials. As a proof of concept, the imprinted apportionment of functional groups within ZIF-8 was achieved by exchanging imine-based linker templates with original linkers initially. The removal of linker fragments by hydrolysis can be achieved via postsynthetic labilization, leading to the formation of architectures with controlled heterogeneity. The distributions of functional groups in the resulting imprinted MOFs can be tuned by judicious control of the interlocked chain length, which was further analyzed by computational methods. This work provides synthetic tools for precise control of pore environment and functionality sequences inside multicomponent materials.
- Feng, Liang,Wang, Kun-Yu,Lv, Xiu-Liang,Powell, Joshua A.,Yan, Tian-Hao,Willman, Jeremy,Zhou, Hong-Cai
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supporting information
p. 14524 - 14529
(2019/10/02)
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- Method for producing aliphatic diamine (by machine translation)
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[Problem] safety, yield, at least one aliphatic diamine having improved simplicity in terms of the method. (1) Formula (2) represented by the formula [a] or the aliphatic diamide, sodium hypochlorite, the presence of a base, a water and alcohol mixture containing alcohol in a solvent comprises the step of - the reaction, the molar ratio of the aliphatic diamide basic, aliphatic diamide (molar ratio)=1.8 - 6.0 in/base, production of aliphatic diamine. [Drawing] no (by machine translation)
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Paragraph 0054; 0055
(2019/07/05)
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- Highly efficient nitrobenzene and alkyl/aryl azide reduction in stainless steel jars without catalyst addition
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The mechanochemical and selective reduction of aryl nitro and aryl/alkyl azide derivatives, with either formate salts or hydrazine, to the corresponding, synthetically useful amines occurs in excellent yields in a planetary ball mill without the addition of a catalyst. This newly developed and solvent-free protocol is efficient, fast and does not require the addition of a metal hydrogenation catalyst as the stainless steel jar itself fulfils that role. The method has been applied to a broad range of compounds and excellent yields have been obtained. The formylation of alkyl amines has been successfully performed, by means of mechanochemical activation, in the presence of ammonium formate alone.
- Martina, Katia,Baricco, Francesca,Tagliapietra, Silvia,Moran, Maria Jesus,Cravotto, Giancarlo,Cintas, Pedro
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supporting information
p. 18881 - 18888
(2018/11/26)
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- Parallel anti-sense two-step cascade for alcohol amination leading to ω-amino fatty acids and α,ω-diamines
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Running two two-step cascades in parallel anti-sense to transform an alcohol to an amine allowed the conversion of ω-hydroxy fatty acids (ω-HFAs) and α,ω-diols to the corresponding ω-amino fatty acids (ω-AmFAs) and α,ω-diamines, respectively. The network required only two enzymes namely an aldehyde reductase (AHR) and a transaminase (TA). Benzylamine served on the one hand as amine donor and on the other hand after deamination to benzaldehyde also as oxidant. All ω-HFAs tested were efficiently transformed to their corresponding ω-AmFAs using purified enzymes as well as a whole-cell system, separately expressing both the enzymes, with conversions ranging from 80-95%. Additionally, a single-cell co-expressing all enzymes successfully produced the ω-AmFAs as well as the α,ω-diamines with >90% yield. This system was extended by employing a lactonase, enabling the transformation of ?-caprolactone to its corresponding ω-AmFA with >80% conversion.
- Sung, Sihyong,Jeon, Hyunwoo,Sarak, Sharad,Ahsan, Md Murshidul,Patil, Mahesh D.,Kroutil, Wolfgang,Kim, Byung-Gee,Yun, Hyungdon
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supporting information
p. 4591 - 4595
(2018/10/23)
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- Diamine compound (by machine translation)
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[Problem] to obtain, dicyano compound is reacted with hydrogen, resulting diamine compound impurities contained in elucidating structure, the impurity content is reduced, a high purity in a high yield in an industrially suitable method for producing a diamine compound. [Solution] nickel catalyst in the presence of a basic compound, a compound represented by general formula (1) is reacted with hydrogen shown dicyano, method for producing a diamine compound, a diamine compound represented by general formula (3) contained in the obtained amide compound content of 0.5% or less as measured by gas chromatography indicated by the area of the, the diamine compound. (1) NC-a Z-to-CN(Z may, of 1 - 20 carbon atoms of straight-chain alkylene group, an alkylene group of a carbon number of 3 - 20 annular, or branched alkylene group of a carbon number of 3 - 20. )(Z is, the synonymous. )[Drawing] no (by machine translation)
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Paragraph 0082; 0083; 0086; 0087
(2017/07/26)
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- Cavitands as Reaction Vessels and Blocking Groups for Selective Reactions in Water
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The majority of reactions currently performed in the chemical industry take place in organic solvents, compounds that are generally derived from petrochemicals. To promote chemical processes in water, we examined the use of synthetic, deep water-soluble cavitands in the Staudinger reduction of long-chain aliphatic diazides (C8, C10, and C12). The diazide substrates are taken up by the cavitand in D2O in folded, dynamic conformations. The reduction of one azide group to an amine gives a complex in which the substrate is fixed in an unsymmetrical conformation, with the amine terminal exposed and the azide terminal deep and inaccessible within the cavitand. Accordingly, the reduction of the second azide group is inhibited, even with excess phosphine, and good yields of the monofunctionalized products are obtained. In contrast, the reduction of the free diazides in bulk solution yields diamine products.
- Masseroni, Daniele,Mosca, Simone,Mower, Matthew P.,Blackmond, Donna G.,Rebek, Julius
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p. 8290 - 8293
(2016/07/19)
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- DIAMINE COMPOUNDS, DINITRO COMPOUNDS AND OTHER COMPOUNDS, AND METHODS OF PRODUCING THEREOF AND USES RELATED THEREOF
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Provided herein are (phenylene)dialkanamines, and methods of producing such (phenylene)dialkanamines from various furanyl and benzyl compounds. Such furanyl compounds may include, for example, bis(nitroalkyl)furans, bis(aminoalkyl)furans, and nitroalkyl(furan)acetonitriles. Such compounds may include, for example, bis(nitroalkyl)benzenes. Provided herein are also alkyldiamines, and methods for producing such alkyldiamines from furanyl compounds.
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Paragraph 0625
(2016/03/22)
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- ACYCLIC ALKENES VIA OZONOLYSIS OF MULTI-UNSATURATED CYCLOALKENES
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A method of making a compound of formula (IIa) by selective ozonolysis of a compound of formula (I) is provided, wherein A is a C6-C10 alkene chain with at least one double bond, R1 is a C1-C10 alkyl, and R3 is an oxygen-containing functional group.
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Paragraph 00158
(2015/02/02)
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- PREPARATION OF PRIMARY DIAMINES HAVING A LINEAR MAIN CHAIN FOR POLYAMIDE SYNTHESES
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The invention provides a method to produce primary diamines by catalytic conversion of diols having a linear main chain of from 4 to 31 carbon atoms into the corresponding diamines. The reaction is conducted in a liquid or supercritical phase and is catalyzed by a homogeneous ruthenium-containing complex. The primary diamines obtained may be suitable for polyamide syntheses.
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Page/Page column 4
(2012/08/27)
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- Redox self-sufficient biocatalyst network for the amination of primary alcohols
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Driving the machinery: A biocatalytic redox-neutral cascade for the preparation of terminal primary amines from primary alcohols at the expense of ammonia has been established in a one-pot one-step method (see picture). Applying this artificial biocatalyst network, long-chain 1,ω-alkanediols were converted into diamines, which are building blocks for polymers, in up to 99 % conversion. Copyright
- Sattler, Johann H.,Fuchs, Michael,Tauber, Katharina,Mutti, Francesco G.,Faber, Kurt,Pfeffer, Jan,Haas, Thomas,Kroutil, Wolfgang
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supporting information
p. 9156 - 9159
(2012/10/30)
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- HYDROGENATION CATALYSTS, THE PRODUCTION AND THE USE THEREOF
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The present invention relates to catalysts and processes for preparation thereof, said catalysts being obtainable by contacting a monolithic catalyst support with a suspension which comprises one or more insoluble or sparingly soluble compounds of the elements selected from the group of the elements cobalt, nickel and copper. The invention further relates to the use of the inventive catalyst in a process for hydrogenating organic substances, especially for hydrogenating nitriles, and to a process for hydrogenating organic compounds, which comprises using an inventive catalyst in the process.
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Page/Page column 11
(2012/01/13)
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- METHOD FOR IMPROVING THE CATALYTIC ACTIVITY OF MONOLITHIC CATALYSTS
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The present invention relates to a process for improving the catalytic properties of a catalyst comprising one or more elements selected from the group consisting of cobalt, nickel and copper, said catalyst being present in the form of a structured monolith, by contacting the catalyst with one or more basic compounds selected from the group of the alkali metals, alkaline earth metals and rare earth metals. The invention further relates to a process for hydrogenating compounds which comprise at least one unsaturated carbon-carbon, carbon-nitrogen or carbon-oxygen bond in the presence of a catalyst comprising one or more elements selected from the group consisting of cobalt, nickel and copper, said catalyst being present in the form of a structured monolith, by contacting the catalyst with one or more basic compounds selected from the group of the alkali metals, alkaline earth metals and rare earth metals. The present invention also relates to the use of a basic compound selected from the group of the alkali metals, alkaline earth metals and rare earth metals for improving the catalytic properties of a catalyst comprising cobalt and/or copper and/or nickel, said catalyst being present in the form of a structured monolith.
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Page/Page column 12
(2012/01/13)
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- METHOD FOR IMPROVING THE CATALYTIC ACTIVITY OF MONOLITHIC CATALYSTS
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The present invention relates to a catalyst comprising one or more elements selected from the group consisting of cobalt, nickel and copper, said catalyst being present in the form of a structured monolith, wherein said catalyst comprises one or more elements selected from the group of the alkali metals, alkaline earth metals and rare earth metals. The invention further relates to processes for preparing the inventive catalyst and to the use of the inventive catalyst in a process for hydrogenating organic substances, especially for hydrogenating nitriles.
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Page/Page column 12-13
(2012/01/13)
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- Functionalized Photoreactive Compounds
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The present invention concerns functionalized photoreactive compounds of formula (I), that are particularly useful in materials for the alignment of liquid crystals. Due to the adjunction of an electron withdrawing group to specific molecular systems bearing an unsaturation directly attached to two unsaturated ring systems, exceptionally high photosensitivities, excellent alignment properties as well as good mechanical robustness could be achieved in materials comprising said functionalized photoreactive compounds of the invention.
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- Environmentally friendly process for the hydrogenation of dinitriles
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Process for converting a dinitrile to a diamine and optionally an aminonitrile, in which a Group VIII element catalyst is treated with a modifier either before or during a substantially solvent-free hydrogenation reaction in which the dinitrile is contacted with hydrogen in the presence of the catalyst.
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- Treatment of bacterial infections
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Compounds which bind to toxins associated with enteric bacterial infection, compositions including the compounds, methods for the neutralization of toxins in a patient, and methods for the diagnosis of bacterial and viral infections are disclosed. Toxins which can be bound by the compounds include pentameric toxins, for example SLTs, such as those from salmonella, camylobacter and other bacteria, verotoxins fromE. coli, cholera toxin, clostridium difficile toxins A and B, bacterial pili from enteropathogenicE. coli(EPEC) and enterotoxigenicE. coli(ETEC) and viral lectins such as viral hemagglutinins. The compounds include a core molecule bound to a plurality of linker arms, which in turn are bound to a plurality of bridging moieties, which in turn are bound to at least one, and preferably, two or more ligands which bind to the toxin. The presence of a plurality of bridged dimers of the ligands is responsible for the increased binding affinity of the compounds relative to the ligands themselves. In one embodiment, the compounds, when administered in a timely fashion to a patient suffering from entericE. coliinfection, inhibit progression of this infection into hemolytic uremic syndrome (HUS).
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- Treatment of bacterial dysentery
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Compounds which bind to shiga-like toxins (SLT) associated with enteric E. coli infection, compositions including the compounds, methods for the neutralization of (SLT) in a patient, and methods for the diagnosis of enteric E. coli infection are disclosed. The compounds include a core molecule bound to a plurality of linker arms, which in turn are bound to a plurality of bridging moieties, which in turn are bound to two or three di- or tri-saccharide moieties. The di- or tri-saccharide moieties themselves are active in binding to the SLTs. The presence of a plurality of bridged dimers of the di- and tri-saccharides is responsible for the increased binding affinity of the compounds relative to the di- and tri-saccharides themselves. The compounds, when administered in a timely fashion to a patient suffering from enteric E. coli infection, inhibit progression of this infection into hemolytic uremic syndrome (HUS).
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- Process for preparing primary amines from aldehydes
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Process for preparing primary amines from aldehydes by mixing an aldehyde with a diluent, where in the case of an alcohol or of water as diluent the mixing temperature is at most 5° C. to prevent the formation of the hemiacetal or the aldehyde hydrate, and bringing the mixture into contact with a mixture of ammonia, hydrogen and hydrogenation catalyst, whereby the formation of an imine is prevented, at temperatures of from 60° to 180° C. and pressures of from 20 to 60 bar, at least 15 mol of ammonia being used per mol of aldehyde group, and also an apparatus for carrying out the process.
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- Hydroboration/Amination of N-Trimethylsilyl Protected Olefinic Amines and Diolefins: Synthesis of Isomerically Pure Diamines
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N-Trimethylsilyl protected olefinic amines and terminal diolefins were hydroborated with dimethylborane and the resulting organoboranes were treated with in situ generated chloramine or chloralkylamines to produce isomerically pure diamines or N-substituted diamines in good yields.
- Kabalka, George W.,Wang, Zhe
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p. 2113 - 2118
(2007/10/02)
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- Process for preparing 1-oxa-3,8-diaza-4-oxo-spiro-[4,5]-decanes
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1-Oxa-3,8-diaza-4-oxo-spiro-[4,5]-decane compounds of the formula STR1 are new light stabilizers for protecting polymers from the damaging effect of UV radiation.
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- Process for producing aliphatic diamine dimers
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A process for producing aliphatic diamine dimers, which comprises heating an aliphatic diamine represented by the general formula, H2NRNH2, wherein R represents an aliphatic group having 7 to 14 carbon atoms,in the presence of at least one catalyst selected from the group consisting of palladium, platinum, rhodium and ruthenium to deammoniate it.
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- Kinetics of Dimerization of Amines By Hydrogen Peroxide in the Presence of Ferrous Sulphate as Catalyst
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Die Kinetik der Dimerisierung von Diethyl-,n-Butyl- und tert.-Butylamin durch Wasserstoffperoxid in Gegenwart von Fe(II)-Ionen wurde untersucht.Diese Reaktion ist bezueglich Fe(II)-Ionen und der Amine 1.Ordnung und 0.Ordnung betreffs Wasserstoffperoxid.Produkte der Dimerisierungsreaktionen sowie einige ihrer kristallinen Derivate wurden erhalten und identifiziert.Die Aktivierungsenergien fuer Diethyl-, n-Butyl- und tert.-Butylamin betragen 153, 130 bzw. 105 KJ mol-1.Ein Reaktionsmechanismus wurde aufgrund der experimentellen Beobachtungen vorgeschlagen.
- Ahmad, Iftikhar,Rauf, A. M. A.,Saeed, Kamal M.
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- Macroheterocycles. III. Synthesis, properties, and tautomeric transformations of macrocyclic thioureas
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Macrocyclic thioureas of the and types, where R=CH2(CH2OCH2)nCH2 and (CH2)m (n=1, 2, 3, m=8), were obtained for the first time by the reaction of diamines with carbon bisulfide.The UV, IR, and PMR spectra of the compounds were studied.It was shown that they exist in the thione form in the crystalline state and in protic solvents.Thione - thiol isomerization is observed in nonpolar solvents.
- Bogatskii, A.V.,Luk'yanenko, N. G.,Kirichenko, T. I.
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p. 1124 - 1129
(2007/10/02)
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- Silicone containing bis-thioether aromatic amines
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A silicone containing bis-thioether aromatic amine has a chemical structure wherein an aromatic nucleus at each end of the chemical radical is chemically bonded to the remainder of the chemical radical by either sulfur, sulfoxide or sulfone.
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- ALKOXYPYRIDYL SUBSTITUTED ALKANES
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The compounds are C 2-C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido) groups. Two compounds of the invention are 1,3-bis-N'-(2-(3-methoxy-2-pyridylmethylthio)ethyl)guanidino!propane and 1-N-(2-(3-methoxy-pyridylmethylthio)ethyl)guanidino!-3-(N'-2-(5-methyl-4-imid azolylmethylthio)ethyl)guanidino!propane. The compounds of this invention are inhibitors of H-2 histamine receptors. "
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