- Α, α-difluoropropionic production of esters
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PROBLEM TO BE SOLVED: To provide a practical method of producing α,α-difluoro esters important as pharmaceutical and agricultural chemical intermediates. SOLUTION: The α,α-difluoro esters are produced by reacting α-halogeno-α-fluoro esters with salts or complexes comprising an organic base and hydrogen fluoride. Dehydrohalogenation of side reaction is controlled in the production method. Only α-fluoro-α,β-unsaturated esters of by-products are treated to be brought specifically into a high boiling-point, a boiling point difference gets remarkably large thereby between the α,α-difluoro ester of an objective product and the unsaturated ester of by-product, and a high purity product of the objective product is efficiently obtained by fractional distillation of a simple operation. The method is the practical method of producing the α,α-difluoro esters capable of solving a problem point in a prior technique. COPYRIGHT: (C)2012,JPOandINPIT
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Paragraph 0098-0100; 0104-0106; 0120-0122
(2016/10/10)
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- MEDICINAL COMPOSITIONS
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The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.
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- Substituted 1,3-thiazole compounds, their production and use
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(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.
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- Antidiabetic agents
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The instant invention is concerned with acetylphenols which are useful as antiobesity and antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering or modulating triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility or for treating atherosclerosis are also disclosed.
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- THERMAL DECOMPOSITION OF 2,2-DIFLUOROPROPIONYL PEROXIDE IN HYDROCARBON SOLVENTS
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The thermal decomposition of 2,2-difluoropropionyl peroxide in heptane is a monomolecular process with a rate constant of 1.1E13 expsec-1.The main gaseous products from the decomposition of the peroxide in heptane and isooctane are 1,1-difluoroethane, 1,1-difluoroethylene, and 2,2,3,3-tetrafluorobutane.The CH3CF2. radicals generated in this process take part in the abstraction of hydrogen atoms from the solvent, disproportionation, and recombination.The decomposition of the peroxide at low initial concentrations in heptane can be used as a method for the generation of CH3CF2. radicals for kinetic investigations.
- Zhuravlev, M. V.,Burmakov, A. I.,Bloshchitsa, F. A.,Sass, V. P.,Sokolov, S. V.
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p. 1597 - 1601
(2007/10/02)
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- REACTION OF KETOCARBOXYLIC ESTERS WITH SULFUR TETRAFLUORIDE IN ANHYDROUS HYDROGEN FLUORIDE
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The reaction of ketocarboxylic esters with sulfur tetrafluoride in anhydrous hydrogen fluoride at 20 deg C gives good yields of difluorocarboxylic esters.Hydrolysis of the latter gave the corresponding carboxylic acids.
- Bloshchitsa, F. A.,Burmakov, A. I.,Kunshenko, B. V.,Alekseeva, L. A.,Bel'ferman, A. L.,et al.
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p. 1260 - 1263
(2007/10/02)
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