- The complex role of the triphenylmethyl motif in anticancer compounds
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Compounds incorporating the triphenylmethyl motif constitute an emerging family of potent anticancer agents. Although several small molecules containing this pharmacophore have now been identified, the mechanism of cell death induction for some of these c
- Palchaudhuri, Rahul,Nesterenko, Vitaliy,Hergenrother, Paul J.
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supporting information; experimental part
p. 10274 - 10281
(2009/02/04)
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- PHOSPHOROUS CONTAINING COMPOUNDS INCLUDING TRIPHENYLMETHYLPHOSPHONATE ESTERS FOR THE TREATMENT OF MELANOMA AND OTHER CANCERS
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Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.
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Page/Page column 59; 1/4
(2008/06/13)
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- Phosphorylation of Adamantane and its Derivatives in Trifluoroacetic Acid Medium
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The possibility of dichlorophosphorylation of the carcass compounds of the adamantane series and of aryl(alkyl)carbinols, with phosphorus trichloride in the low-nucleophilicity trifluoroacetic acid medium was first demonstrated. A new preparative method for introducing a POCl2 group into the bridgehead and bridge positions of the adamantane nucleus, as well as into the α position of the side chain was developed. Some intermediate adamantyl cations may undergo isometizations, among them skeleton ones. A mechanism of the phosphorylation was proposed.
- Shokova,Erokhin,Kovalev
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p. 1624 - 1634
(2007/10/03)
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- Organophosphorus Compounds with Tertiary Alkyl Substituents, II: Synthesis and Characterization of Triphenylmethyl-Substituted λ4P(V) Compounds; Crystal Structure of Triphenylmethylphosphonic Difluoride
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The synthesis of the triphenylmethyl-phosphonic and -phosphonothioic dihalides Ph3CP(:X)Y2 (X=O, S; Y=F, Cl) is described.The NMR parameters of these compounds are discussed and compared to these of other phosphonic and thiophosphonic dihalides.Single cry
- Goerlich, Jens R.,Fischer, Axel,Jones, Peter G.,Plack, Volker,Schmutzler, Reinhard
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p. 341 - 347
(2007/10/02)
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