- Acid-promoted reaction of N-(cyanomethyl) amide with nitrosation reagent: Facile synthesis of 1,2,4-oxadiazole-3-carboxamide
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1,2,4-Oxadiazole-3-carboxamide has been extensively used in the pharmaceutical chemistry. In this study, 1,2,4-oxadiazole-3-carboxamide is accomplished through an acid-promoted reaction of N-(cyanomethyl)amide with nitrosation reagent. This novel preparat
- Du, Shaoqing,Fu, Wen,Li, Jin,Qian, Xuhong,Shao, Xusheng,Xu, Xiaoyong
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supporting information
(2021/06/15)
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- Hydroxamic Acids as Potent Inhibitors of FeII and MnII E. coli Methionine Aminopeptidase: Biological Activities and X-ray Structures of Oxazole Hydroxamate-EcMetAP-Mn Complexes
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New series of acids and hydroxamic acids linked to five-membered heterocycles including furan, oxazole, 1,2,4- or 1,3,4-oxadiazole, and imidazole were synthesized and tested as inhibitors against the FeII, CoII, and MnII f
- Huguet, Florian,Melet, Armelle,Alves de Sousa, Rodolphe,Lieutaud, Aurelie,Chevalier, Jacqueline,Maigre, Laure,Deschamps, Patrick,Tomas, Alain,Leulliot, Nicolas,Pages, Jean-Marie,Artaud, Isabelle
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scheme or table
p. 1020 - 1030
(2012/07/31)
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- Nitrosation of methyl 2-acylamino-3-dimethylaminopropenoates. A simple conversion of N-acylglycines into 5-substituted 1,2,4-oxadiazole-3-carboxylates
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A novel simple synthesis of 5-substituted-1,2,4-oxadiazole-3-carboxylates 5 from N-acylglycines 1, which are transformed with DMF in the presence of phosphorus oxychloride into 2-substituted-4-dimethylaminomethyleneoxazol-5(4H)-ones 2, followed by opening
- Kmetic,Stanovnik
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p. 1563 - 1565
(2007/10/03)
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- A New Synthetic Method of Alkyl Carbonocyanidate N-Oxides
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A thermal decomposition of dimethyl nitromalonate to bis(carbomethoxy)furoxan was observed at about 170 deg C.In the presence of dipolarophiles, an intermediate, methyl carbonocyanidate N-oxide MeOCOCN->O, could be trapped as cycloadducts in good yields b
- Shimizu, Tomio,Hayashi, Yoshiyuki,Teramura, Kazuhiro
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p. 2519 - 2522
(2007/10/02)
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