Secondary Phosphine Oxide Preligands for Palladium-Catalyzed C–H (Hetero)Arylations: Efficient Access to Pybox Ligands
C–H arylations of oxazolines were accomplished with a well-defined palladium catalyst derived from a secondary bisdiamantyl phosphine oxide. The single-component secondary phosphine oxide (SPO)-palladium complex enabled C–H activations with aryl bromides
Synthesis of modular thiophene-oxazoline ligands and their application in the asymmetric phenyl transfer reaction to aldehydes
A series of thiophene mono (oxazoline) N,O-ligands with three sites of diversity were synthesized concisely in two steps from the corresponding thiophene carbonitriles. These ligands were applied to the enantioselective phenyl transfer reaction of aldehydes, resulting in the corresponding chiral diaryl methanol products with excellent yields and moderate to good enantioselectivities.
Chai, Zhuo,Liu, Xin-Yuan,Wu, Xiao-Yu,Zhao, Gang
p. 2442 - 2447
(2007/10/03)
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.
Heerding, Dirk A.,Chan, George,DeWolf Jr., Walter E.,Fosberry, Andrew P.,Janson, Cheryl A.,Jaworski, Deborah D.,McManus, Edward,Miller, William H.,Moore, Terrance D.,Payne, David J.,Qiu, Xiayang,Rittenhouse, Stephen F.,Slater-Radosti, Courtney,Smith, Ward,Takata, Dennis T.,Vaidya, Kalindi S.,Yuan, Catherine C.K.,Huffman, William F.
p. 2061 - 2065
(2007/10/03)
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