374927-12-5

Basic information

• Product Name: Boronic acid, [4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]- (9CI)
• Synonyms: Boronic acid, [4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]- (9CI);(4-((4-METHYLPIPERAZIN-1-YL)CARBONYL)PHENYL)BORONIC ACID
• CAS NO: 374927-12-5
• Molecular Formula: C₁₂H₁₇BN₂O₃
• Molecular Weight: 248.08598
• Product Categories: BORONICACID;Boronate Ester;Boronic Acid;Potassium Trifluoroborate
• Mol File: 374927-12-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Boronic acid, [4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Boronic acid, [4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]- (9CI)(374927-12-5)
• EPA Substance Registry System: Boronic acid, [4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]- (9CI)(374927-12-5)

Safety Data

• Hazardous Substances Data: 374927-12-5(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 14047-29-1 4-carboxyphenylboronic acid 
• 349395-87-5 (4-bromophenyl)-(4-methylpiperazin-1-yl)methanone 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 1242772-49-1 C₂₁H₂₂N₄O₂ 
• 1314882-84-2 {4-[2-amino-3-(2-methoxypyridin-5-yl)pyridin-5-yl]phenyl}(4-methylpiperazin-1-yl)methanone 
• 1190219-68-1 5-[4-(4-methylpiperazine-1-carbonyl)-phenyl]-furan-2-carboxylic acid [4-(9-benzenesulfonyl-9H-carbazol-2-yl)-thiazol-2-yl]-amide 
• 1175276-34-2 [4-(6-Amino-5-benzothiazol-2-ylpyridin-3-yl)phenyl]-(4-methylpiperazin-1-yl)methanone 

Relevant articles and documents

INDOLINONE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring C, X1, X2, L1, R1, R2, R3, R4, R5, R6, R7, m and n are as defined herein, which are useful as MAP4K1 inhibitors, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by MAP4K1.

3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted-2H-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.

Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimers Disease: Design, synthesis, and characterization of pyrazines

Glycogen synthase kinase-3β, also called tau phosphorylating kinase, is a proline-directed serine/threonine kinase which was originally identified due to its role in glycogen metabolism. Active forms of GSK3β localize to pretangle pathology including dystrophic neuritis and neurofibrillary tangles in Alzheimers disease (AD) brain. By using a high throughput screening (HTS) approach to search for new chemical series and cocrystallization of key analogues to guide the optimization and synthesis of our pyrazine series, we have developed highly potent and selective inhibitors showing cellular efficacy and bloo-brain barrier penetrance. The inhibitors are suitable for in vivo efficacy testing and may serve as a new treatment strategy for Alzheimers disease.

Antiproliferative compounds and therapeutic uses thereof

Inhibitors of the oncogenic tyrosine kinase ALK and of the Bcr-Abl mutant T315I Bcr-Abl, such as a compound of formula (I): wherein Q, T, W, K, J, Y, X, Z are independently selected from C, N, S, O, provided that the corresponding rings are (hetero)aromatic; n = 0 or 1; q = 1 or 2; pharmaceutical compositions containing the same and their use for the treatment of hyper-proliferative diseases.

SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS

The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction