- Preparation and pharmacological activities of 10-homolupinanoyl-2-R- phenothiazines
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Pursuing our researches on quinolizidinyl derivatives of phenothiazine and on the ground of antidepressive, diuretic, antianginal and antiarrhythmic activities of several 10-(3-dialkylamino) propionylphenothiazines (as chloracizine, moricizine, etc.), six
- Sparatore,Sparatore
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- Degradation kinetics and mechanisms of moricizine hydrochloride in acidic medium
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The degradation kinetics of moricizine hydrochloride (1) were examined over a pH range of 0.6 to 6.0 at an ionic strength of 0.3 and 60 °C. The disappearance of intact 1 was followed by a stability-indicating HPLC assay. The degradation products, which had approximate solubilities of 2.8. At pH >4.0, the reverse Mannich product was the predominant degradation product. Degradation of 1 was subject to positive and negative kinetic salt effects at pH 1.0 and 4.0, respectively. Arrhenius plots determined at pH 1.0 and 6.0 were linear between 37 and 70 °C. Predicted shelf lives at room temperature (22 °C) at pH 1.0 and 6.0 were identical to the shelf lives determined experimentally.
- King,Sigvardson,Dudzinski,Torosian
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p. 586 - 591
(2007/10/02)
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