Intermolecular Hydroamination of 1,3-Dienes to Generate Homoallylic Amines
We report a Rh-catalyzed hydroamination of 1,3-dienes to generate homoallylic amines. Our work showcases the first case of anti-Markovnikov selectivity in the intermolecular coupling of amines and 1,3-dienes. By tuning the ligand properties and Br?nsted acid additive, we find that a combination of rac-BINAP and mandelic acid is critical for achieving anti-Markovnikov selectivity.
Visible-light photoredox-promoted desilylative allylation of α-silylamines: An efficient route to synthesis of homoallylic amines
A facile and efficient synthesis of homoallylic amines by visible-light photoredox-promoted desilylative allylation of α-silylamines with allylic sulfones is described. A variety of α-silylamines derived from anilines, cyclic and acyclic alkyl amines reacted with a serious of mono or disubstituted allylic sulfones well to provide homollylic amines in good to high yields under very mild reaction conditions.