- SYNTHESIS, STRUCTURE, AND REACTIVITY OF 1,2,3,6-TETRAHYDROPYRIMIDINE-2-THIONES
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Dehydration of 4-hydroxyhexahydropyrimidine-2-thiones formed 1,2,3,6-tetrahydropyrimidine-2-thiones containing no substituent at the C(4) carbon atom.It is shown that the synthesized compounds, in contrast to their 4-alkyl-substituted analogs, react easily with various nucleophilic reactants (alcohols,butylmercaptan, benzenesulfinic acid, hydrazoic acid, p-toluidine) to from the corresponding 4-functionally substituted hexahydropyrimidine-2-thiones.
- Shutalev, A. D.,Komarova, E. N.,Pagaev, M. T.,Ignatova, L. A.
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p. 1077 - 1086
(2007/10/02)
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- A novel tautomerism in alkyl dihydropyrimidines: Observation of tautomerism by H-D exchange of 2- and/or 4-methyl protons of dihydropyrimidines in CD3OD
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A novel tautomerism was found in dihydropyrimidines such as 2-amino-4,6,6-trimethyldihydropyrimidine 1 and 2,4,6,6-tetramethyldihydropyrimidine 2 by the observation of H-D exchange on both 4-methyl protons of 1 and 2,4-dimethyl protons of 2 by the treatme
- Kim, Yong Hae,Lim, Byoung Uk
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p. 2057 - 2060
(2007/10/02)
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- Synthesis of Heterocyclic Compounds via Enamines. Part 8. Acid-catalysed Transformations in 4,4,6-Trimethyl-1,4-Dihydropyrimidine-2(3H)-thione Derivatives and Related Compounds
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1-Substituted 4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)-thiones (2) on heating in 11M-HCl at 100-110 deg C are converted into the corresponding 2-substituted-amino-4,6,6-trimethyl-6H-1,3-thiazines (4) and/or thioureas.But at 95-100 deg C, Dimroth rearrangement products, e.g. the corresponding 2-substituted-amino-4,4,6-trimethyl-4H-1,3-thiazenes (3) are formed.
- Singh, Harjit,Singh, Paramjit
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p. 1013 - 1018
(2007/10/02)
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