- ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS OR PRECURSORS THEREOF
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Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate to urolithins and urolithin precursors and use thereof. Certain urolithins are represented by Formula I, while certain urolithin precursors are represented by Formula IV. The urolithin may be urolithin A, urolithin B, urolithin C, or urolithin D. The urolithin precursor may be ellagic acid or an ellagitannin. The methods include in vivo, ex vivo, and in vitro uses of the compounds and compositions.
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- Synthesis of 1,2,4-trimethoxybenzene and its selective functionalization at C-3 by directed metalation
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A new and efficient strategy was developed for the preparation of 1,2,4-trimethoxybenzene (3, a powerful attractant of Euglossini bees) and its C-3 derivatives (7a-j), from vanillin (2) in 56% overall yield.
- Alves, Ana P. L.,Junior, Jose Augusto B. C.,Slana, Glaucia B. A.,Cardoso, Jari N.,Wang, Qiang,Lopes, Rosangela S. C.,Lopes, Claudio C.
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experimental part
p. 3693 - 3709
(2009/12/06)
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- Nonsteroidal selective glucocorticoid modulators: The effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-lh-[1]benzopyrano[3,4-f]quinolines
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The preparation and characterization of a series of C-10 substituted 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines as a novel class of selective ligands for the glucocorticoid receptor is described. Substitution at the C-10 positi
- Kym, Philip R.,Kort, Michael E.,Coghlan, Michael J.,Moore, Jimmie L.,Tang, Rui,Ratajczyk, James D.,Larson, Daniel P.,Elmore, Steven W.,Pratt, John K.,Stashko, Michael A.,Douglass Falls,Lin, Chun W.,Nakane, Masake,Miller, Loan,Tyree, Curtis M.,Miner, Jeffery N.,Jacobson, Peer B.,Wilcox, Denise M.,Nguyen, Phong,Lane, Benjamin C.
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p. 1016 - 1030
(2007/10/03)
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