One-pot synthesis of polysubstituted 3-amino-2-oxo-2,7-dihydro-1 H -azepines
A facile and efficient synthesis of novel seven-membered heterocyclic derivatives containing 3-aminoazepan-2-one backbone is described using 1,4-protected piperazine-2,5-diones and alkynes as starting materials. The reaction may undergo Michael? addition,
Transannular rearrangement of activated 2,5-diketopiperazines: A key route to original scaffolds
An efficient and original stereocontrolled transannular rearrangement starting from activated 2,5-diketopiperazines has been developed, an opportunity for the medicinal chemistry field, which requests access to novel biological scaffolds. This powerful ri
Farran, Daniel,Parrot, Isabelle,Toupet, Loic,Martinez, Jean,Dewynter, Georges
experimental part
p. 3989 - 3996
(2009/06/28)
SYNTHESES OF BENZOYLPIPERAZINE DIONES FROM THEIR BENZYL COUNTERPARTS
The first synthesis of 2,5-dibenzoylpiperazine-3,6-diones through a selective FeCl3-H2O-UV promoted photooxidation of the corresponding benzyl methylene groups is reported.This reaction has been also applied to NN'-dibenzylpiperazine-2,5-dione and to a p-
Barbier, Michel
p. 345 - 348
(2007/10/02)
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