- Preparation method of climbazole
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The invention discloses a preparation method of climbazole. According to the method, toluene, chloroetherketone, imidazole and a catalyst, serving as raw materials, react under 100 DEG C to 110 DEG Cfor 4 hours while the temperature is kept, and then the climbazole with the purity being up to 99 percent is prepared by methods, such as crystallization, purification, alkaline wash and recrystallization. Through a lot of experiments, the invention screens out the best climbazole preparation method, the whole process design is reasonable, the process is easy and efficient to operate, in particular, the best reaction conditions screened out, which include catalyst variety, reaction solvent, reaction temperature, reaction time and steps, such as crude reaction of methylbenzene and the climbazole, and alkaline wash thereof, can greatly increase reaction yield (up to 92 percent or above), side reaction is reduced, the reaction rate is increased, the production cost is greatly reduced, and therefore the preparation method of the climbazole has a good application prospect.
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Paragraph 0048; 0061; 0062; 0064; 0067; 0070; 0073
(2018/04/03)
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- NOVEL NEISSERIA MENINGITIDIS SEROGROUP Y OLIGOMER AND PROCESS FOR SYNTHESIZING THEREOF
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The present invention relates to novel oligomers of Neisseria meningitidis serogroup Y capsular polysaccharide repeating unit (Men-Y oligomers) and process for synthesizing novel Men- Y oligomers. Inparticular, the present invention relates to the chemical synthesis of the tetramer of Men- Y capsular polysaccharide repeating unit capable of being used as a candidate in the development of semisynthetic or fully synthetic conjugate vaccine against meningococcal serogroup Y bacterial infection.
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Paragraph 0048; 0061; 0064; 0067; 0070; 0073
(2018/04/03)
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