New and practical synthesis of 1,4-dihydrobenzopyrano-pyrazoles
A new method for the synthesis of 1,4-dihydrobenzopyranopyrazoles using bromovinyl hydrazones has been described involving a [3+2] intramolecular cycloaddition.
Unified Approach to Pyrazole-Fused Heterocyclic and Carbocyclic Motifs through One-Pot Condensation and Intramolecular Dipolar Cycloaddition Reaction
A one-pot synthesis of highly substituted pyrazoles that are fused to dihydrochromenes, dihydroquinolines and cyclopentane motifs, from readily available precursors is reported. The reaction involves conversion of alkyne-tethered aldehydes into the corresponding tosylhydrazones, base-mediated generation of diazo compounds, and subsequent intramolecular dipolar cycloaddition reaction. A range of internal and terminal alkynes as well as bromoalkyne compounds can be employed as the tethered dipolarophile to afford the corresponding cycloadducts.
Divya, K. Vijay L.,Meena,Suja, Thachapully D.
p. 4207 - 4212
(2016/11/26)
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