38093-76-4

Basic information

• Product Name: 2-methyl-4-phenylthiazol-5-Amine
• Synonyms: 2-methyl-4-phenylthiazol-5-Amine;2-methyl-4-phenyl-5-Thiazolamine;2-methyl-4-phenylthiazol-5-ylamine
• CAS NO: 38093-76-4
• Molecular Formula: C₁₀H₁₀N₂S
• Molecular Weight: 190.2648
• Mol File: 38093-76-4.mol

Chemical Properties

• Boiling Point: 349.7 °C at 760 mmHg
• Flash Point: 165.3 °C
• Appearance: /
• Density: 1.219 g/cm³
• CAS DataBase Reference: 2-methyl-4-phenylthiazol-5-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-phenylthiazol-5-Amine(38093-76-4)
• EPA Substance Registry System: 2-methyl-4-phenylthiazol-5-Amine(38093-76-4)

Safety Data

• Hazardous Substances Data: 38093-76-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-methyl-4-phenylthiazol-5-Amine is used as a key intermediate in the development of new pharmaceutical drugs due to its unique structure and reactivity. Its potential biological activities, such as anti-inflammatory and antioxidant properties, make it a promising candidate for the treatment of various diseases and conditions.
Used in Organic Synthesis:
2-methyl-4-phenylthiazol-5-Amine is used as a valuable building block in the synthesis of complex organic molecules. Its unique structure and reactivity allow for the creation of a wide range of compounds with diverse applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 1041436-27-4 (2-methyl-4-phenylthiazol-5-yl)-(1,1,3,3-tetramethylbutyl)amine 
• 16750-42-8 2-amino-2-phenylacetonitrile 
• 39149-34-3 2-acetamido-2-phenylacetonitrile 
• 53641-60-4 2-phenylglycinonitrile hydrochloride 
• 75-07-0 acetaldehyde 
• 54167-92-9 (2-methyl-4-phenyl-thiazol-5-yl)-carbamic acid benzyl ester 
• 54167-78-1 (1-chloro-2-oxo-2-phenyl-ethyl)-carbamic acid benzyl ester 

Downstream Products

• 1610565-88-2 1-(1',4-dimethyl-1-phenyl-1H,1'H-[3,4'-bipyrazol]-5-yl)-3-(2-methyl-4-phenylthiazol-5-yl)urea 

Relevant articles and documents

THIAZOLYL AND OXAZOLYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS

The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates thereof, that bind to Inhibitor of Apoptosis Proteins (IAPs). The compounds of the invention may be used as diagnostic and therapeutic agents in the

Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling

A flexible route to novel 5-aminothiazoles has been developed based on cyclisation of diamide adducts, prepared using the Ugi reaction, in the presence of Lawesson's reagent. The Walborsky reagent (1,1,3,3-tetramethylbutyl isocyanide) was used as the isonitrile component, facilitating subsequent deprotection of the N-alkyl group to yield free 5-aminothiazoles, which were prepared with a variety of substituents at the 2- and 4-positions.

Inhibitors of IAP

The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.

THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY

The invention provides compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A, R1, R2 and R3 are as defined in the specification; a process for their preparation; pharmaceutical compositions con