38115-13-8Relevant articles and documents
COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Paragraph 0314; 0341; 0342; 0343, (2018/02/27)
Compounds of formula (I) wherein: Ak1 represents an alkyl chain, X represents —(CH2)m—, —CH(R)—, —N(R)—, —CH2—N(R)—, —N(R)—CH2— or —CH2—N(R)—CH2—, m and R are as defined in the description, R1 and R2 each represent H when X represents —(CH2)m—, —CH(R)—, —N(R)—, —CH2—N(R)— or —N(R)—CH2—, or together form a bond when X represents —CH2—N(R)—CH2—, R3 represents NH2, Cy-NH2, Cy-Ak3-NH2 or piperidin-4-yl, Cy and Ak3 are as defined in the description, R4 and R5, which may be identical or different, each represent H or F, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating conditions requiring a TAFIa inhibitor.
Highly efficient and versatile synthesis of polyarylfluorenes via Pd-catalyzed C-H bond activation
Hwang, Seung Jun,Kim, Hyun Jin,Chang, Sukbok
supporting information; experimental part, p. 4588 - 4591 (2009/12/09)
A facile protocol for the Pd-catalyzed preparative synthesis of fluorene derivatives has been developed. While a wide range of fluorenes were easily obtained with high efficiency and selectivity under mild conditions, excellent functional group tolerance
Synthesis and evaluation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus
Fournier dit Chabert, Jeremie,Marquez, Beatrice,Neville, Luc,Joucla, Lionel,Broussous, Sylvie,Bouhours, Pascale,David, Emilie,Pellet-Rostaing, Stephane,Marquet, Bernard,Moreau, Nicole,Lemaire, Marc
, p. 4482 - 4497 (2008/03/13)
The synthesis based on palladium catalytic coupling of 38 new-arylated benzo[b]thiophenes or thiophenes is described in a few steps. We also report the direct arylation of the position 3 of the benzo[b]thiophenic structure, a 'one pot' 2,5-heterodiarylati
Extension of the Heck reaction to the arylation of activated thiophenes
Lavenot,Gozzi,Ilg,Orlova,Penalva,Lemaire
, p. 49 - 55 (2007/10/03)
The direct arylation of activated thiophenes was accomplished in moderate to good yields using a Heck-type reaction with the mixture of Pd(OAc)2 and n-Bu4NBr as a catalytic system. This new arylation method is applied to different derivatives and has proved to be compatible with sensitive functional groups. Furthermore, the substituent nature and position on the thiophene moiety influence the cross coupling. In particular the substitution is regiospecific when the heterocycle is substituted at position 2 with an electron withdrawing group.
Direct thiophene arylation catalysed by palladium
Gozzi, Christel,Lavenot, Laurence,Ilg, Kerstin,Penalva, Vincent,Lemaire, Marc
, p. 8867 - 8870 (2007/10/03)
Direct thiophene arylation using a Heck-type reaction with Pd(OAc)2/NBu4Br as catalytic system is reported. Reactions with 2- and 3-substituted thiophenes have shown that substituent nature and position influence the cross-coupling.
