- Nitrogen-containing heterocyclic compound and medicinal composition and application thereof
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The invention provides a nitrogen-containing heterocyclic compound with a structure represented by a formula I, or a pharmaceutically acceptable salt, a stereoisomer or a prodrug molecule thereof, and a pharmaceutical composition and application thereof. The compound and the pharmaceutically acceptable salt thereof have an inhibition effect on RIOK2 protease, can effectively inhibit the growth of various tumor cells, and can be used for preparing antitumor drugs.
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Paragraph 0091-0095
(2021/05/29)
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- CARBODITHIOATES WITH SPERMICIDAL ACTIVITY AND PROCESS FOR PREPARATION THEREOF
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The present invention relates to the synthesis and biological evaluation of compound of formula I as spermicidal agents, and its pharmaceutically acceptable acid salt thereof. The invention provides bis(4- substituted-1-piperazinylthiocarbonyl) disulfide (when n = 0) and alkane-1,n-diylbis(4-substituted piperazine-1-carbodithioate) (when n = 0, 1, 2 or 3) as shown in figure 1 of the accompanying drawing. These compounds are found to be useful for spermicidal activity.
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Page/Page column 45
(2014/08/20)
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- Design, synthesis and molecular docking studies of novel triazole as antifungal agent
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In order to meet the urgent need for novel antifungal agents with improved activity and broader spectrum, a series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4- difluorophenyl)-3-[(4-substituted trifluoromethyl phenyl)-piperazin-1-yl]- propan-2-ols were designed,
- Chai, Xiaoyun,Zhang, Jun,Cao, Yongbing,Zou, Yan,Wu, Qiuye,Zhang, Dazhi,Jiang, Yuanying,Sun, Qingyan
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experimental part
p. 3167 - 3176
(2011/06/27)
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- New 1-aryl-3-substituted propanol derivatives as antimalarial agents
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This paper describes the synthesis and in vitro antimalarial activity against a P. falciparum 3D7 strain of some new 1-aryl-3-substituted propanol derivatives. Twelve of the tested compounds showed an IC50 lower than 1 μM. These compounds were
- Perez-Silanes, Silvia,Berrade, Luis,Garcia-Sanchez, Rory N.,Mendoza, Adela,Galiano, Silvia,Perez-Solorzano, Berta Martin,Nogal-Ruiz, Juan J.,Martinez-Fernandez, Antonio R.,Aldana, Ignacio,Monge, Antonio
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experimental part
p. 4120 - 4135
(2010/03/04)
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